Results 101 to 110 of about 5,637,228 (331)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Journal of Pharmacological Sciences, 2007 There are few efficacious medications for drug dependence at present. Recent evidence has suggested that various cytokines are involved in the effects of abused drugs, suggesting that these factors play a role in drug dependence.
Minae Niwa +3 more
doaj +1 more source
People and Nature, 2020 Sense of place holds promise to understand how people perceive and respond to social and ecological change; however, using this concept to explore vulnerability and adaptation first depends on identifying the multiple ways people define their ...
Kiandra Rajala +2 more
doaj +1 more source
Validation of the New Mix Design Process for Cold In-Place Rehabilitation Using Foamed Asphalt, 2007
, 2007 Asphalt pavement recycling has grown dramatically over the last few years as a viable technology to rehabilitate existing asphalt pavements. Iowa's current Cold In-place Recycling (CIR) practice utilizes a generic recipe specification to define the ...
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Place of buprenorphine in the management of opioid dependence
, 2009 Buprenorphine is a partial agonist at μ opioid receptors and has been used extensively in pain management. Its use in the management of opioid dependence has occurred in the last decade although its potential has been recognized from the late 1970s ...
Mattick, Richard P. +2 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Linking activity and place attachment dimensions in enhancing the sense of place [PDF]
, 2007 Sense of place definition includes the point where the physical form, activity and meaning are intertwined in the people experience of a place. In urban design and place quality research, much has been discussed on the influence of the physical form ...
Ujang, Norsidah, Dola, Kamariah
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source