Results 81 to 90 of about 5,637,228 (331)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

MODELING KEY SELECTED MULTISENSORY DIMENSIONS ON PLACE SATISFACTION AND PLACE ATTACHMENT AMONG TOURISTS IN VICTORIA FALLS, ZIMBABWE [PDF]

open access: yesGeo Journal of Tourism and Geosites, 2019
This study investigated the influence of multisensory dimensions on place satisfaction and attachment in the African tourism context. Using a data set consisting of 151 tourists who had visited the Victoria Falls of Zimbabwe, the study examines the ...
Modjadji Matilda MASHAPA   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Methanolic extract of Morinda citrifolia L. (noni) unripe fruit attenuates ethanol-induced conditioned place preferences in mice

open access: yesFrontiers in Pharmacology, 2016
Phytotherapy is an emerging field successfully utilized to treat various chronic diseases including alcohol dependence. In the present study, we examined the effect of the standardized methanolic extract of Morinda citrifolia Linn. unripe fruit (MMC), on
Yasmin Khan, Vijayapandi Pandy
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Linking Perceived Biodiversity and Restorative Benefits in Urban Parks through Place Attachment—A Case Study in Fuzhou, China

open access: yesDiversity
Enhanced understanding of environmental restoration can be achieved by examining how urban park visitors’ perceptions of biodiversity contribute to their sense of environmental rejuvenation.
Jingru Chen   +3 more
doaj   +1 more source

Transversality and Transition: Branching to New Regional Path Dependence [PDF]

open access: yes
Since Paul David published his economic histories of path dependent innovation the subject has exerted fascination upon scholars of innovation, technological change and, latterly, regional scientists and economic geographers.
Philip Cooke
core  

Branding Åland, branding Ålanders : reflections on place identity and globalization in a Nordic archipelago

open access: yes, 2012
The process commonly called globalization is associated with, among other things, an increasing economic connectedness and dependence between places, as well as the long-distance migration of people from and to all corners ofthe world.
Jansson, David,
core   +1 more source

Proenvironmental behavior: Critical link between satisfaction and place attachment in Australia and Canada [PDF]

open access: yes, 2017
This study explores issues of scale equivalence and generalizability in national parks. Visitors' place satisfaction, proenvironmental behavior, and place attachment are measured across two qualitatively distinct populations in Australia and Canada ...
Mavondo, F. T.   +7 more
core   +1 more source

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