Results 1 to 10 of about 370,076 (166)

Improvements in sleep indices during exam stress due to consumption of a Bifidobacterium longum

Brain, Behavior, & Immunity - Health, 2021
Targeting the gut microbiome as an effective therapeutic strategy for psychological disorders has shown promise in recent years. Variation in the composition of the microbiota and restoration of a stable microbiome using targeted interventions ...
Gerard M. Moloney, Caitriona M. Long-Smith, Amy Murphy, Danielle Dorland, Sara Firuzeh Hojabri, Loreto Olavarría Ramirez, David Campos Marin, Thomaz F.S. Bastiaanssen, Anne-Marie Cusack, Kirsten Berding, Fiona Fouhy, Andrew P. Allen, Catherine Stanton, Gerard Clarke, Timothy G. Dinan, John F. Cryan   +15 more
doaj   +1 more source

Towards Extending the Detection Window of Gamma-Hydroxybutyric Acid—An Untargeted Metabolomics Study in Serum and Urine Following Controlled Administration in Healthy Men

Metabolites, 2021
In forensic toxicology, gamma-hydroxybutyrate (GHB) still represents one of the most challenging drugs of abuse in terms of analytical detection and interpretation.
Andrea E. Steuer, Justine Raeber, Fabio Simbuerger, Dario A. Dornbierer, Oliver G. Bosch, Boris B. Quednow, Erich Seifritz, Thomas Kraemer   +7 more
doaj   +1 more source

Successful Strategies and Areas of Improvement–Lessons Learned from Design and Conduction of a Randomized Placebo-Controlled Trial in Palliative Care, ‘Palliative-D’

Life, 2021
Clinical trials in palliative care are challenging to design and conduct. Burden on patients should be minimized, while gatekeeping by professionals and next-of kin needs to be avoided.
Maria Helde Frankling, Caritha Klasson, Linda Björkhem-Bergman   +2 more
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Safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WBP216, a novel IL-6 monoclonal antibody, in patients with rheumatoid arthritis: A phase Ia randomized placebo-controlled study

Frontiers in Immunology, 2023
BackgroundWBP216 is a novel human immunoglobulin G1 (IgG1) monoclonal antibody for interleukin (IL)-6. We aimed to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of a single ascending dose (SAD) of WBP216 in patients ...
Xiaomei Leng, Xiange Tang, Pei Hu, Xiaoduo Guan, Qian Li, Cipo Huang, Qiang Zhang, Rui Chen, Xiaofeng Zeng   +8 more
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Safety, tolerability, and immunogenicity of a CpG/Alum adjuvanted SARS-CoV-2 recombinant protein vaccine (ZR202-CoV) in healthy adults: Preliminary report of a phase 1, randomized, double-blind, placebo-controlled, dose-escalation trial

Human Vaccines & Immunotherapeutics, 2023
This was a phase 1 dose-escalation study of ZR202-CoV, a recombinant protein vaccine candidate containing a pre-fusion format of the spike (S)-protein (S-trimer) combined with the dual-adjuvant system of Alum/CpG.
Guang-Wei Feng, Zhong-Fang Wang, Peng He, Qin-Ying Lan, Ling Ni, Ya-Zheng Yang, Chen-Fei Wang, Ting-Ting Cui, Li-Li Huang, Yong-Qiang Yan, Zhi-Wei Jiang, Qing Yang, Bang-Wei Yu, Xi Han, Jing-Jing Chen, Shu-Yuan Yang, Lin Yuan, Ling-Yun Zhou, Ge Liu, Ke Li, Zhen Huang, Jin-Cun Zhao, Zhong-Yu Hu, Zhi-Qiang Xie   +23 more
doaj   +1 more source

Efficacy and Safety of Fluticasone Furoate Nasal Spray in Japanese Children with Perennial Allergic Rhinitis: A Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

Allergology International, 2014
Background:: Fluticasone furoate nasal spray (FFNS) is a glucocorticoid developed for the treatment of allergic rhinitis (AR). This is the first randomized clinical trial to assess the efficacy and safety of FFNS in Japanese children with perennial AR ...
Kimihiro Okubo, Arisa Okamasa, Gosuke Honma, Masaki Komatsubara   +3 more
doaj   +1 more source

Surgical “Placebo” Controls

Annals of Surgery, 2002
To set ethical guidelines on the use of surgical placebo controls in the design of surgical trials.Ethical concerns recently arose from surgical trials where subjects in the control arm underwent surgical procedures that had the appearance of a therapeutic intervention, but during which the essential therapeutic maneuver was omitted. Although there are
Robert, Tenery, Herbert, Rakatansky, Frank A, Riddick, Michael S, Goldrich, Leonard J, Morse, John M, O'Bannon, Priscilla, Ray, Sherie, Smalley, Matthew, Weiss, Audiey, Kao, Karine, Morin, Andrew, Maixner, Sam, Seiden   +12 more
openaire   +3 more sources

Safety and immunogenicity of primary vaccination with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: Two randomized, observer-blinded, placebo-controlled and dose-escalation phase 1 clinical trials

Human Vaccines & Immunotherapeutics, 2023
Vaccination plays a key role in preventing morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to evaluate the safety and immunogenicity of a SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccine ...
Gui-Ling Chen, Yuan-Zheng Qiu, Kai-Qi Wu, Ying Wu, Yuan-Hui Wang, Yu-Ying Zou, Cong-Gao Peng, Jie Zhao, Chang Su, Jun-Heng Ma, Shao-Nan Ni, Xing Wang, Ting-Han Jin, Qi Jiang, Tong Guo, Yan Xu, Chao-Chao Huang, Qing Zhang, Kai-Li Liu, Li Ji, Han-Yu Yang, Chun-Lei Li, Yu-Wen Su, Xiang Lu, Lan-Juan Li   +24 more
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Commentary of "Placebo Studies in Developing Countries: Ethical, but not Ideal"

Voices in Bioethics, 2014
In his piece, Scott is against the notion that using placebos as controls (when there is an existing treatment method) in randomized controlled trials (RCTs) is never ethical.
Marilyn Eshikena
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Flunarizine in Alternating Hemiplegia

Pediatric Neurology Briefs, 1988
The effects of flunarizine, a calcium-entry blocker, in alternating hemiplegia are reported in the first 12 children included in an international study coordinated from the Dept Pediatrics, University Hospital Gasthuisberg, B-3000 Leuven, Belgium.
J Gordon Millichap
doaj   +1 more source