Results 141 to 150 of about 17,568,133 (310)

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial.

The Lancet Oncology, 2017
E. Pujade-Lauraine, J. Ledermann, F. Selle, V. Gebski, R. Penson, A. Oza, J. Korach, T. Huzarski, A. Poveda, S. Pignata, M. Friedlander, N. Colombo, P. Harter, K. Fujiwara, I. Ray-Coquard, Susana Banerjee, Joyce F. Liu, E. Lowe, R. Bloomfield, P. Pautier   +19 more
semanticscholar   +1 more source

Tranexamic Acid Use in Hip Arthroscopy Reduces Bleeding Without Increased Risk of Major Complications: A Systematic Review

Arthroscopy, EarlyView.
Purpose To critically evaluate the impact of tranexamic acid (TXA) on hip arthroscopy outcomes, including its effects on bleeding, functional recovery, postoperative pain, complications, intraoperative visualization, and surgical efficiency. Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic ...
Paul B. Walker, Mathangi Sridharan, Adrian Lin, Atousa Nourmahnad, Alexander Fish, Sharon L. Hame, Kristofer J. Jones   +6 more
wiley   +1 more source

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.

The Lancet, 2019
Z. Younossi, V. Ratziu, R. Loomba, M. Rinella, Q. Anstee, Z. Goodman, P. Bedossa, A. Geier, S. Beckebaum, P. Newsome, D. Sheridan, M. Sheikh, J. Trotter, W. Knapple, E. Lawitz, M. Abdelmalek, K. Kowdley, A. Montaño-Loza, J. Boursier, P. Mathurin, E. Bugianesi, G. Mazzella, A. Olveira, H. Cortez‐Pinto, I. Graupera, D. Orr, L. Gluud, J. Dufour, D. Shapiro, J. Campagna, L. Zaru, L. Macconell, R. Shringarpure, S. Harrison, A. Sanyal   +34 more
semanticscholar   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

Effects of Ubiquinol on Oxidized Low-Density Lipoprotein in Prediabetic Patients: A Randomized, Double-Blinded, Placebo-Controlled Study. [PDF]

Biomed Res Int
Leaovitavat R, Palakornkitti P, Thetsana P, Teng-Umnuay P.   +3 more
europepmc   +1 more source

A Phase 2 Trial of Hydroxychloroquine in Individuals at Risk for Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Individuals with serum elevations of anti–cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA in such at‐risk individuals.
Kevin D. Deane, Christopher C. Striebich, Marie L. Feser, James R. O'Dell, Judith A. James, Jeffrey A. Sparks, John M. Davis III, Jonathan Graf, Maureen A. McMahon, Elizabeth B. Solow, Lindsy J. Forbess, Athan Tiliakos, Elena Schiopu, Maria I. Danila, Diane L. Horowitz, Jonathan Kay, Colin D. Strickland, Joel M. Guthridge, Cristina Arriens, Jennifer M. Grossman, M. Kristen Demoruelle, Elizabeth A. Bemis, Ashley Frazer‐Abel, Chelsie L. Fleischer, David A. Fox, Ted R. Mikuls, Melissa Greenleaf, Kate York, Sarah Walker, Lynette Keyes‐Elstein, Margie Byron, Janel Fedler, Ellen A. Goldmuntz, V. Michael Holers   +33 more
wiley   +1 more source

Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study. [PDF]

J Headache Pain
Fitzek MP, Kleist P, Handtmann C, Overeem LH, Hoehne CL, Lange KS, Angerhöfer C, Salim Y, Ebert AD, Mattern N, Reuter U, Raffaelli B.   +11 more
europepmc   +1 more source

Placebo controls, exorcisms, and the devil [PDF]

The Lancet, 2009
Ted J, Kaptchuk, Catherine E, Kerr, Abby, Zanger   +2 more
openaire   +2 more sources

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Efficacy and Safety of SA001 in Patients with Primary Sjögren's Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. [PDF]

Pharmaceuticals (Basel)
Park J, Seo KY, Ahn H, Shin Y, Jun I, Kim TI, Shin BK, Yoon DY, Lee SM.   +8 more
europepmc   +1 more source