Results 251 to 260 of about 17,568,133 (310)
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Moclobemide — Placebo-controlled trials
International Clinical Psychopharmacology, 1993In this paper, three placebo-controlled trials of moclobemide, and four three-way comparison trials of moclobemide, placebo and one of the standard tricyclic antidepressants, imipramine, clomipramine, or amitriptyline, are reviewed. The results of the placebo-controlled trials indicate that about twice as many of the patients receiving moclobemide ...
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Lancet, The, 2019
BACKGROUND No approved therapies exist for neuromyelitis optica spectrum disorder (NMOSD), a rare, relapsing, autoimmune, inflammatory disease of the CNS that causes blindness and paralysis.
Brian G Weinshenker +2 more
exaly +2 more sources
BACKGROUND No approved therapies exist for neuromyelitis optica spectrum disorder (NMOSD), a rare, relapsing, autoimmune, inflammatory disease of the CNS that causes blindness and paralysis.
Brian G Weinshenker +2 more
exaly +2 more sources
Ophthalmology (Rochester, Minn.), 2019
PURPOSE Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0.025 ...
J. Yam +10 more
semanticscholar +1 more source
PURPOSE Low-concentration atropine is an emerging therapy for myopia progression, but its efficacy and optimal concentration remain uncertain. Our study aimed to evaluate the efficacy and safety of low-concentration atropine eye drops at 0.05%, 0.025 ...
J. Yam +10 more
semanticscholar +1 more source
The Lancet, 2020
BACKGROUND Rimegepant is a calcitonin gene-related peptide receptor antagonist that has shown efficacy and safety in the acute treatment of migraine.
Robert Croop +8 more
semanticscholar +1 more source
BACKGROUND Rimegepant is a calcitonin gene-related peptide receptor antagonist that has shown efficacy and safety in the acute treatment of migraine.
Robert Croop +8 more
semanticscholar +1 more source
Empirical evidence against placebo controls
Journal of Medical Ethics, 2017The revised Declaration of Helsinki allows placebo-controlled trials to be used even when there is an established therapy, provided there are adequate ‘methodological’ reasons for doing so. This seems to violate the principle of beneficence: where there is an established therapy, physicians treating patients with a placebo are withholding a known ...
Batra, S, Howick, J
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The Lancet, 2019
BACKGROUND Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation, hepatocellular injury, and progressive liver fibrosis.
S. Harrison +11 more
semanticscholar +1 more source
BACKGROUND Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation, hepatocellular injury, and progressive liver fibrosis.
S. Harrison +11 more
semanticscholar +1 more source
The Journal of Experimental Education, 1990
This article reports a review and meta-analysis of placebo control groups in educational experiments. Studies were clustered into control procedures that included explicit manipulation of attentional elements (Attn + ), explicit descrip tion of the placebo activity plus implied reference to attention (Act + ), and exclusive reference to the activity ...
John G. Adair +2 more
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This article reports a review and meta-analysis of placebo control groups in educational experiments. Studies were clustered into control procedures that included explicit manipulation of attentional elements (Attn + ), explicit descrip tion of the placebo activity plus implied reference to attention (Act + ), and exclusive reference to the activity ...
John G. Adair +2 more
openaire +1 more source
The Ethics of Placebo‐controlled Trials: A Comparison of Inert and Active Placebo Controls
World Journal of Surgery, 2005AbstractBecause of the recent and controversial example of sham surgery for the evaluation of fetal tissue transplants for Parkinson’s disease, there is renewed interest in the ethics of using “active” placebos in surgical trials, where otherwise there are no inert procedures available, and in pharmacological trials, where there are inert substances ...
Sarah J L, Edward +4 more
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Placebo Controlled Trials: Restrictions, Not Prohibitions
Cambridge Quarterly of Healthcare Ethics, 2004The last two decades have witnessed intense debate over the ethical legitimacy of placebo controlled trials (PCTs). Most of the arguments for and against the use of PCTs turn on one of the following issues: (1) the compatibility of the obligations of clinicians and researchers with PCTs, (2) the scientific merit of PCTs, and (3) the influence of ...
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