Results 21 to 30 of about 17,568,133 (310)

Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study

Medicina, 2023
Background and Objectives: Although acupuncture is listed as a beneficial treatment for neck/shoulder stiffness, which has increased with the spread of information technology, to date, evidence of its efficacy under double-blind conditions has not been ...
Nobuari Takakura, Miho Takayama, Akiko Kawase, Ted J. Kaptchuk, Jian Kong, Mark Vangel, Hiroyoshi Yajima   +6 more
doaj   +1 more source

PLACEBO USE IN THE CONTEXT OF INFLAMMATORY BOWEL DISEASE CLINICAL TRIALS [PDF]

Arquivos de Gastroenterologia, 2020
Inflammatory bowel disease comprises two distinct conditions - Crohn’s disease and ulcerative colitis - which can be treated with immunomodulators.
Juan Sebastian LASA, Ignacio ZUBIAURRE, Astrid RAUSCH, Pablo OLIVERA   +3 more
doaj   +1 more source

MULTICENTER DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED TRIAL OF THE SYMPTOM- AND STRUCTURE-MODIFYING EFFECT OF ALFLUTOP IN PATIENTS WITH KNEE OSTEOARTHROSIS. COMMUNICATION 1. EVALUATION OF THE SYMPTOM-MODIFYING EFFECT OF THE DRUG

Научно-практическая ревматология, 2013
Objective: to evaluate the symptom- and structure-modifying effect of alflutop versus placebo (PL) in patients with knee osteoarthrosis (OA).Subjects and methods.
Lyudmila Ivanovna Alekseeva, E P Sharapova, E A Taskina, N V Chichasova, G R Imametdinova, N A Shostak, N G Pravdyuk, L N Denisov   +7 more
doaj   +1 more source

Attitudes toward Placebo-Controlled Clinical Trials of Patients with Schizophrenia in Japan. [PDF]

PLoS ONE, 2015
Although the use of placebo in clinical trials of schizophrenia patients is controversial because of medical and ethical concerns, placebo-controlled clinical trials are commonly used in the licensing of new drugs.The objective of this study was to ...
Norio Sugawara, Masamichi Ishioka, Shoko Tsuchimine, Koji Tsuruga, Yasushi Sato, Hanako Furukori, Shuhei Kudo, Tetsu Tomita, Taku Nakagami, Norio Yasui-Furukori   +9 more
doaj   +1 more source

Proof of Concept Trial of Dronabinol in Obstructive Sleep Apnea

Frontiers in Psychiatry, 2013
Study Objective: Animal data suggest that ∆9-TetraHydroCannabinol (∆9THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing and blocks serotonin-induced exacerbation of sleep apnea.
Bharati ePrasad, Miodrag G Radulovacki, David W Carley   +2 more
doaj   +1 more source

Challenges of conducting a randomised placebo-controlled trial of spinal surgery: the SUcceSS trial of lumbar spine decompression

Trials, 2023
Although placebo-controlled trials are considered the gold standard for evaluating the efficacy of healthcare interventions, they can be perceived to be controversial and challenging to conduct for surgical treatments.
Emma Kwan-Yee Ho, Ralph Jasper Mobbs, James Montague van Gelder, Ian Andrew Harris, Gavin Davis, Ralph Stanford, David John Beard, Christopher Gerard Maher, Joanna Prior, Michael Knox, David Barrett Anderson, Rachelle Buchbinder, Manuela Loureiro Ferreira   +12 more
doaj   +1 more source

Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.

The Lancet Respiratory Medicine, 2020
BACKGROUND A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in systemic sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial lung disease (SSc-ILD) in a phase 3 trial to investigate the safety and ...
D. Khanna, Celia J. F. Lin, D. Furst, J. Goldin, G. Kim, M. Kuwana, Y. Allanore, M. Matucci-Cerinic, O. Distler, Y. Shima, J. V. van Laar, H. Spotswood, Bridget Wagner, J. Siegel, A. Jahreis, C. Denton   +15 more
semanticscholar   +1 more source

Prednisone Therapy for Duchenne Dystrophy

Pediatric Neurology Briefs, 2005
The effects of prednisone on muscle function and the extent of steroid-related adverse effects were studied in 17 ambulant children with Duchenne muscular dystrophy (DMD) at University Hospital, Groningen; Rehabilitation Centre, Utrecht; and Leiden ...
J Gordon Millichap
doaj   +1 more source

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.

The Lancet, 2016
BACKGROUND Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease.
M. Armstrong, P. Gaunt, G. Aithal, D. Barton, D. Hull, R. Parker, J. Hazlehurst, K. Guo, G. Abouda, M. Aldersley, Deborah D. Stocken, S. Gough, J. Tomlinson, Rachel M. Brown, S. Hübscher, P. Newsome   +15 more
semanticscholar   +1 more source

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Loki zupa in Patients With Chronic Asthma

Frontiers in Pharmacology, 2018
The purpose of this study was to evaluate the efficacy and safety of Uyghur medical formula Loki zupa in patients with chronic asthma. Adult patients with chronic asthma randomly received placebo or Loki zupa as add-on to inhaled corticosteroids (ICS ...
Yubao Lv, Yubao Lv, Ying Wei, Ying Wei, Muhammadjan Abduwaki, Tohti Jurat, Fengsen Li, Huaizhen Wang, Yuhua Wu, Zheng Li, Bo Liu, Hongjun Yin, Yuxue Cao, Yuxue Cao, Mammat Nurahmat, Zihui Tang, Zihui Tang, Jingcheng Dong, Jingcheng Dong   +18 more
doaj   +1 more source