Results 61 to 70 of about 17,568,133 (310)

Bezafibrate as treatment in males for Barth syndrome: CARDIOMAN, a double-blind, placebo-controlled crossover RCT

Efficacy and Mechanism Evaluation
Background Barth syndrome is a rare, life-threatening X-linked recessive mitochondrial disorder of lipid metabolism primarily affecting males. Previous research suggests that bezafibrate may ameliorate cellular lipid abnormalities and reduce cardiac ...
Guido Pieles, Colin Steward, Lucy Dabner, Laura Collet, Lucy Culliford, Karen Sheehan, Lucy Ellis, Michaela Damin, Eva Sammut, Nuno Duarte, Owen Burgess, Curtis Wadey, Craig Williams, John Crosby, Sarah Groves, Aidan Searle, Borko Amulic, Chris Rice, Chiara Bucciarelli-Ducci, Andrew Ness, Julian Hamilton-Shield, Chris A Rogers, Barnaby C Reeves   +22 more
doaj   +1 more source

Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies

Frontiers in Nutrition
Pycnogenol® French maritime pine bark extract is a well-known and thoroughly studied patented extract from the bark of Pinus pinaster Ait. ssp. Atlantica.
Franziska Weichmann, Peter Rohdewald
doaj   +1 more source

Unethical use of placebo controls [PDF]

British Journal of Psychiatry, 2002
Klysner et al ([2002][1]) evaluated the prophylactic efficacy of citalopram in comparison with placebo in elderly patients, and stated ‘the highly recurrent nature of major depression in the young and the elderly warrants long-term antidepressant treatment’.
A. K. Jainer, N. Soni
openaire   +1 more source

Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis–Associated Uveitis or Chronic Anterior Antinuclear Antibody–Positive Uveitis

Arthritis Care &Research, EarlyView.
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Y. Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review

BMC Medicine, 2008
Background Randomised trials comparing different drugs head-to-head are extremely valuable for clinical decision-making. However, it is scientifically and ethically sensible to demand strong evidence that a drug is effective by showing superiority over a
Bossuyt Patrick M, Steurer Johann, Vollenweider Daniela, Puhan Milo A, ter Riet Gerben   +4 more
doaj   +1 more source

The Renal Activity Index for Lupus Identifies Active Renal Disease and Treatment Response in Adult Patients With Systemic Lupus Erythematosus and Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective We evaluated the ability of the Renal Activity Index for Lupus (RAIL) to discriminate active lupus nephritis (LN) in adult patients with active systemic lupus erythematosus (SLE) and differentiate LN treatment response. Methods Urine samples from adults with biopsy‐proven active class III and IV LN from TULIP‐LN (active LN group ...
Hermine I. Brunner, Ellen M. Cody, Prasad Devarajan, Bin Huang, Chen Chen, Dominic Sinibaldi, Madhu Ramaswamy, Jacob Knagenhjelm, Frederick Jones, Philip Z. Brohawn, Raj Tummala, Catharina Lindholm, Wendy I. White   +12 more
wiley   +1 more source

Oxcarbazepine Adjunctive Therapy for Partial Seizures

Pediatric Neurology Briefs, 2000
The safety and efficacy of oxcarbazepine (OXC) as adjunctive therapy for refractory partial seizures were evaluated in 267 patients in a multicenter (47 centers in 8 countries; Argentina, Chile, Uruguay, Australia, New Zealand, Canada, Israel, and the ...
J Gordon Millichap
doaj   +1 more source

A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy

Journal of Psychoactive Drugs, 2020
After a two-decade hiatus in which research on psychedelics was essentially halted, placebo-controlled clinical trials of psychedelic-assisted therapy for mental health conditions have begun to be published.
J. Luoma, Christina Chwyl, Geoff J. Bathje, Alan K. Davis, R. Lancelotta   +4 more
semanticscholar   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Barriers to participation in a placebo-surgical trial for lumbar spinal stenosis

Heliyon, 2019
Background: Placebo-controlled trials are an important tool when assessing the efficacy of spinal surgical procedures. The most common spinal surgical procedure in older adults is decompression for lumbar spinal stenosis.
David B. Anderson, Ralph J. Mobbs, Jillian Eyles, S. Eileen Meyer, Gustavo C. Machado, Gavin A. Davis, Ian A. Harris, Rachelle Buchbinder, Manuela L. Ferreira   +8 more
doaj   +1 more source