This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John+5 more
wiley +1 more source
Objective: To compare the mean postoperative pain score following Transversus Abdominis Plane block versus placebo, in patients undergoing elective total Abdominal Hysterectomy under general anaesthesia.
Raja Muhammad Bilal+2 more
doaj
Gabapentin for pain management after osmotic dilator insertion and prior to dilation and evacuation: A randomized controlled trial. [PDF]
ObjectiveTo evaluate if gabapentin 600 mg reduces pain after osmotic dilator placement the day before a dilation and evacuation (D&E) procedure.Study designWe conducted a double-blind, placebo-controlled, randomized (stratified by vaginal parity ...
Chen, Melissa J+5 more
core +3 more sources
Effect of tibolone on breast cancer cell proliferation in postmenopausal ER+ patients: Results from STEM trial [PDF]
Purpose: Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized, placebo-controlled pilot trial to investigate the ...
Dowsett, Mitch+10 more
core +2 more sources
Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.
BACKGROUND BG-12 (dimethyl fumarate) was shown to have antiinflammatory and cytoprotective properties in preclinical experiments and to result in significant reductions in disease activity on magnetic resonance imaging (MRI) in a phase 2, placebo ...
R. Gold+10 more
semanticscholar +1 more source
Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms
Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee+10 more
wiley +1 more source
Neuroimaging Studies of Antidepressant Placebo Effects: Challenges and Opportunities
Over the last two decades, neuroscientists have used antidepressant placebo probes to examine the biological mechanisms implicated in expectancies of mood improvement.However, findings from these studies have yet to elucidate a model-based theory that ...
Vanessa Brown, Marta Peciña
doaj +1 more source
Effects of Coloring Food Images on the Propensity to Eat: A Placebo Approach With Color Suggestions
BackgroundResearch findings on the appetite-enhancing effect of the color red and the appetite-reducing effect of blue have been inconsistent. The present study used a placebo approach and investigated whether verbal suggestions can enhance color ...
Carina Schlintl, Anne Schienle
doaj +1 more source
Reversal of hepatorenal syndrome type 1 with terlipressin plus albumin vs. placebo plus albumin in a pooled analysis of the OT-0401 and REVERSE randomised clinical studies [PDF]
Background The goal of hepatorenal syndrome type 1 (HRS-1) treatment is to improve renal function. Terlipressin, a synthetic vasopressin analogue, is a systemic vasoconstrictor used for the treatment of HRS-1, where it is available.
Araya, V.+11 more
core +2 more sources
Transcranial photobiomodulation (PBM) enhances spatial working memory in healthy rats under both continuous and alternating stimulation protocols. At the neural level, PBM modulates cytochrome c oxidase activity, increases prefrontal and hippocampal synaptic markers, and induces region‐specific c‐Fos expression. These effects suggest improved cognitive
Candela Zorzo+6 more
wiley +1 more source