Results 181 to 190 of about 1,543,966 (410)

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma

New England Journal of Medicine, 2018
A. Eggermont, C. Blank, M. Mandalà, G. Long, V. Atkinson, S. Dalle, A. Haydon, M. Lichinitser, A. Khattak, M. Carlino, S. Sandhu, J. Larkin, S. Puig, P. Ascierto, P. Rutkowski, D. Schadendorf, R. Koornstra, L. Hernandez-Aya, M. Maio, A. V. D. van den Eertwegh, J. Grob, R. Gutzmer, R. Jamal, P. Lorigan, N. Ibrahim, S. Marréaud, A. V. van Akkooi, S. Suciu, C. Robert   +28 more
semanticscholar   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Placebo-resistant gut bacteria: Akkermansia muciniphila spp. and Familial Mediterranean fever disease

Frontiers in Cellular and Infection Microbiology
IntroductionDespite numerous investigations into the impact of drugs/probiotics on the gut microbiota composition in Familial Mediterranean Fever (FMF) patients, the question as to whether there exists a significant bacterial diversity(ies) independent ...
Elya Pepoyan, Elya Pepoyan, Elya Pepoyan, Francesco Marotta, Anahit Manvelyan, Anahit Manvelyan, Artak Galstyan, Lena Stepanyan, Lena Stepanyan, Hasmik Grigoryan, Hasmik Grigoryan, Liana Grigoryan, Mikayel Mikayelyan, Mikayel Mikayelyan, Marine Balayan, Marine Balayan, Natalya Harutyunyan, Natalya Harutyunyan, Susanna Mirzabekyan, Susanna Mirzabekyan, Vardan Tsaturyan, Vardan Tsaturyan, Tamas Torok, Astghik Pepoyan, Astghik Pepoyan   +24 more
doaj   +1 more source

A Randomized Placebo-Controlled Efficacy Study of a Prime Boost Therapeutic Vaccination Strategy in HIV-1-Infected Individuals: VRI02 ANRS 149 LIGHT Phase II Trial

, 2021
Yves Lévy, Christine Lacabaratz, Édouard Lhomme, Aurélie Wiedemann, Claire Bauduin, Craig Fenwick, Emile Foucat, Mathieu Surénaud, Lydia Guillaumat, Valérie Boilet, Véronique Rieux, O. Bouchaud, Pierre Marie Girard, Jean‐Michel Molina, Philippe Morlat, Laurent Hocqueloux, Laura Richert, Giuseppe Pantaleo, Jean‐Daniel Lelièvre, Rodolphe Thiébaut   +19 more
openalex   +1 more source

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

New England Journal of Medicine, 2017
D. Rolnik, D. Wright, L. Poon, N. O’Gorman, A. Syngelaki, Catalina de Paco Matallana, R. Akolekar, S. Cicero, D. Janga, Mandeep Singh, F. Molina, N. Persico, J. Jani, W. Plasencia, G. Papaioannou, K. Tenenbaum‐Gavish, H. Meiri, S. Gizurarson, K. Maclagan, K. Nicolaides   +19 more
semanticscholar   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Psychotherapy and Placebos: Manifesto for Conceptual Clarity

Frontiers in Psychiatry, 2018
Charlotte R. Blease, Charlotte R. Blease
doaj   +1 more source

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

New England Journal of Medicine, 2017
X. Montalban, S. Hauser, L. Kappos, D. Arnold, A. Bar-Or, G. Comi, J. de Seze, G. Giovannoni, H. Hartung, B. Hemmer, F. Lublin, K. Rammohan, K. Selmaj, A. Traboulsee, A. Sauter, D. Masterman, P. Fontoura, S. Belachew, H. Garren, N. Mairon, P. Chin, J. Wolinsky   +21 more
semanticscholar   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Effects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: a randomized, double-blind, placebo-controlled trial

, 2020
Flávia Rasmussen Faria, Aline Corado Gomes, Alisson Henrique Antunes, Kênnia Rocha Rezende, Gustavo D. Pimentel, Camila Lemos Pinto Oliveira, Barbara Moura Antunes, Fábio Santos Lira, Marcelo Saldanha Aoki, João Felipe Mota   +9 more
openalex   +2 more sources