Results 191 to 200 of about 522,910 (321)

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats. [PDF]

Commun Biol
Boorman DC, Crawford LS, Henderson LA, Keay KA.   +3 more
europepmc   +1 more source

d-Amphetamine raises serum prolactin in man: Evaluations after chronic placebo, lithium and pimozide treatment

, 1978
Daniël P. van Kammen, John P. Docherty, Stephen R. Marder, Samuel G. Siris, William E. Bunney   +4 more
openalex   +1 more source

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew, Matthew P. Doogue, Richard McNeill, Mei Zhang, Julia J. Rucklidge, Christopher M. Frampton, Roger T. Mulder, Ben Beaglehole   +7 more
wiley   +1 more source

Revolutionizing Chinese medicine granule placebo with a machine learning four-color model. [PDF]

Chin Med
Teng T, Zhang J, Miao P, Liang L, Song X, Liu D, Zhang J.   +6 more
europepmc   +1 more source

Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design. [PDF]

, 1984
Craig M. Pratt, James B. Young, Marilyn J. Francis, Addison A. Taylor, H. James Norton, La Dean English, D. E. Mann, Helen A. Kopelen, Miguel A. Quiñones, Robert Roberts   +9 more
openalex   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Psychotherapy and Placebo [PDF]

British Journal of Psychiatry, 1986
openaire   +8 more sources

Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial. [PDF]

BMC Med
Omlor W, Cecere G, Huang GY, Spiller T, Misra AR, Rabe F, Kallen N, Kirschner M, Surbeck W, Burrer A, Garibaldi G, Holiga Š, Dukart J, Umbricht D, Homan P.   +14 more
europepmc   +1 more source

Efficacy and safety of moricizine in patients with ventricular tachycardia: results of a placebo-controlled prospective long-term clinical trial. [PDF]

, 1986
Craig M. Pratt, Ann Wierman, A.Allen Seals, La Dean English, Carlos León, James B. Young, Miguel A. Quiñones, Robert Roberts   +7 more
openalex   +1 more source