Results 211 to 220 of about 522,910 (321)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Unveiling the efficacy and safety of Erenumab, a monoclonal antibody targeting calcitonin gene-related peptide (CGRP) receptor, in patients with chronic and episodic migraine: a GRADE-assessed systematic review and meta-analysis of randomized clinical trials with subgroup analysis. [PDF]

Head Face Med
Haseeb ME, Mohammed HE, Yaser H, Hanen G, Nasser M, Yaser S, Bady Z.   +6 more
europepmc   +1 more source

Treatment of Men with Idiopathic Oligozoospermic Infertility Using the Aromatase Inhibitor, Testolactone Results of a Double‐Blinded, Randomized, Placebo‐Controlled Trial with Crossover [PDF]

, 1989
Richard V. Clark, Richard J. Sherins
openalex   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise. [PDF]

Nat Commun
Shekarriz S, Szamosi JC, Whelan FJ, Lau JT, Libertucci J, Rossi L, Fontes ME, Wolfe M, Lee CH, Moayyedi P, Surette MG.   +10 more
europepmc   +1 more source

A Placebo-Controlled Double-Blind Crossover Investigation of the Side Effects Attributed to Oral Contraceptives

, 1971
Joseph W. Goldzieher, Louis E. Moses, E. G. Averkin, Cora Scheel, Ben Z. Taber   +4 more
openalex   +1 more source

A three year follow up of patients allocated to placebo, or oral or injectable gold therapy for rheumatoid arthritis. [PDF]

, 1986
H A Capell, D. C. Lewis, John Carey
openalex   +1 more source

On blaming the placebo [PDF]

Arthritis & Rheumatism, 1991
Curtis J. Henke, Wallace V. Epstein
openaire   +3 more sources

Placebo treatment entails resource-dependent downregulation of negative inputs. [PDF]

Sci Rep
Mostauli A, Rauh J, Gamer M, Büchel C, Rief W, Brassen S.   +5 more
europepmc   +1 more source

Non-specific urethritis. A placebo-controlled trial of minocycline in conjunction with laboratory investigations.

, 1976
M J Prentice, D Taylor‐Robinson, G. W. Csonka   +2 more
openalex   +1 more source