Results 231 to 240 of about 1,543,966 (410)

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis

New England Journal of Medicine, 2017
M. Wechsler, P. Akuthota, D. Jayne, P. Khoury, A. Klion, C. Langford, P. Merkel, F. Moosig, U. Specks, M. Cid, R. Luqmani, Judith E. Brown, S. Mallett, R. Philipson, S. Yancey, J. Steinfeld, P. Weller, G. Gleich   +17 more
semanticscholar   +1 more source

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

Annals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek, David F. Hanff, Pim J. French, Sarah A. van Dijk, Erik A.C. Wiemer, Olivier C. Manintveld, Martin J. van den Bent, Walter Taal   +7 more
wiley   +1 more source

Fuzuloparib with or without apatinib as maintenance therapy in newly diagnosed, advanced ovarian cancer (FZOCUS-1): A multicenter, randomized, double-blind, placebo-controlled phase 3 trial. [PDF]

CA Cancer J Clin
Wu L, Wang J, Li Q, Wang D, Zhang C, Tang J, Zhang G, Hao M, Yao D, Gao Q, Zhang Y, An R, Yin R, Wang L, Xia B, Zhou Q, Yang H, Zhu J, Jiang K, Chen Z, Wu Q, Duan W, Huang Y, Zhang H, Wei S, Li G, Meng Y, Wang K, Yang X, Huang X, Pan L, Yu J, Lou G, Zhang Y, Zhou H, Guo X, Yang H, Cheng X, Li X, Wang W, Zhao H, Li Y, Yang Y, Lin A, Cheng W, Chen L, Xie X, Di W, Hu Y, Chen M, Wen H, Cai L, Wu X, Lin Z, Wang Q, Yang X, Li N.   +56 more
europepmc   +1 more source

INDUSTRY FUNDING AND PLACEBO QUIT RATE IN CLINICAL TRIALS OF NICOTINE REPLACEMENT THERAPY: A COMMENTARY ON ETTER ET AL. (2007) [PDF]

, 2010
NATASHA M. P. GREENE, Eleanor Taylor, Suzanne H. Gage, Marcus R. Munafò   +3 more
openalex   +1 more source

Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
D. Dodick, S. Silberstein, M. Bigal, P. Yeung, P. Goadsby, Tricia Blankenbiller, M. Grozinski‐Wolff, Ronghua Yang, Yuju Ma, E. Aycardi   +9 more
semanticscholar   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial. [PDF]

Endocrinol Diabetes Metab
Bourbour F, Mahdavi B, Naghshi N, Yari Z, Hosseini SM, Kalbasi S, Sohrab G.   +6 more
europepmc   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Haemodynamic Changes After Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine Versus Placebo During Induction of General Anaesthesia: A Randomised Trial. [PDF]

Acta Anaesthesiol Scand
Sjøen GH, Hauge TH, Falk RS, Tønnessen TI, Langesæter E.   +4 more
europepmc   +1 more source

Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo‐controlled, multicenter study

, 2017
Hyun‐Jin Lee, Min‐Beom Kim, Shin‐Young Yoo, Shi Nae Park, Eui‐Cheol Nam, In Seok Moon, Ho‐Ki Lee   +6 more
openalex   +2 more sources