Results 231 to 240 of about 1,501,016 (387)

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai   +4 more
wiley   +1 more source

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

open access: yesScience, 2004
T. Wager   +8 more
semanticscholar   +1 more source

Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high‐dose insulin therapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan   +3 more
wiley   +1 more source

A network meta-analysis of efficacy and safety of adjuvant targeted therapy or immunotherapy in non-small cell lung cancer. [PDF]

open access: yesSci Rep
Sa-Nguansai S   +6 more
europepmc   +1 more source

Sentinel dosing: A proposed algorithm to guide decision making on which cohorts in early phase clinical pharmacology trials should use this approach

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this paper is to describe a proposal for an algorithm to guide decision making on which cohorts in early phase pharmacology trials should employ a sentinel approach, thereby standardising and harmonising practices, and improving decision making around sentinel dosing.
Jules A. A. C. Heuberger   +5 more
wiley   +1 more source

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