Results 91 to 100 of about 14,264,655 (329)

Short-term impact of aged garlic extract on endothelial function in diabetes: A randomized, double-blind, placebo-controlled trial. [PDF]

, 2020
Impaired endothelial function portends an increased risk of cardiovascular disease. Vascular oxidative stress and systemic inflammation play a critical role in the pathogenesis and progression of vascular disease.
Birudaraju, Divya, Budoff, Matthew J, Chaganti, Bhanu T, Cherukuri, Lavanya, Flores, Ferdinand, Hamal, Sajad, Kinninger, April, Matsumoto, Suguru, Roy, Sion K, Shaikh, Kashif   +9 more
core  

Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]

, 2007
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland, Esparza, Fitzgerald, Harbige, Harbige, Jones, Karpus, Laurence S. Harbige, Mohammad K. Sharief, Mokhtarian, Ovadia, Santambrogio, Selmaj, Serafina, Thompson, Thompson, Vartanian   +16 more
core   +2 more sources

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney ...
J. Rosenstock, V. Perkovic, O. Johansen, M. Cooper, S. Kahn, N. Marx, J. Alexander, M. Pencina, R. Toto, C. Wanner, B. Zinman, H. Woerle, David Baanstra, E. Pfarr, S. Schnaidt, T. Meinicke, J. George, M. von Eynatten, D. McGuire   +18 more
semanticscholar   +1 more source

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei, Qian Liu, Guoxin Liu, Manjie Zhang, Jiaxin Fang, Xuting He, Xueqi He, Zhengwei Qin, Ronghua Liu, Chuang Liu, Hongyu Ji, Yuechao Dong, Ye Yuan, Baofeng Yang, Weijie Du   +14 more
wiley   +1 more source

New evidence on taxes and portfolio choice [PDF]

, 2009
Identifying the effect of differential taxation on portfolio allocation requires exogenous variation in marginal tax rates. Marginal tax rates vary with income, but income surely affects portfolio choice directly. In systems of individual taxation – like
Alan, S, Atalay, K, Crossley, TF, Jeon, SH   +3 more
core   +2 more sources

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Glucose and cognitive performance : the effects of glucose on memory and sustained attention : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]

, 2004
The effects of glucose on tasks of declarative memory, and sustained attention were examined. These effects were also investigated with regard to the age of the participant.
Richardson, Kelly
core  

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure [PDF]

, 2007
Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Aicher, A, Dimmeler, S, Freyssinet, JM, Haase, A, Hoffmann, J, Hugel, B, Mallat, Z, Rossig, L, Tedgui, A, Zeiher, AM   +9 more
core   +1 more source

Placebo effect in osteoarthritis: Why not use it to our advantage?

World Journal of Orthopaedics, 2015
Osteoarthritis is a major cause of pain and reduced quality of life in the elderly, as well as a major economic burden. Unfortunately, there is no currently effective therapeutic strategy to prevent the progression of Osteoarthritis, and its treatment ...
G. C. de Campos
semanticscholar   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source