Results 71 to 80 of about 12,173,418 (313)

Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial. [PDF]

, 2008
BACKGROUND: Malaria is a major cause of morbidity and mortality in early childhood, yet its consequences for health and education during the school-age years remain poorly understood.
Brooker, Simon, Jukes, Matthew C.H., Estambale, Benson Ba, Khasakhala, Lincoln, Crudder, Christopher, Njagi, J Kiambo, Cundill, Bonnie, Njagi, Kiambo J., Jukes, Matthew Ch, Clarke, Siân, Otido, Julius, Estambale, Benson B., Clarke, Siân E, Estambale, Benson B.A., Jukes, Matthew C H, Jukes, Matthew   +15 more
core   +1 more source

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

The placebo effect

, 2018
“Placebo: a usually pharmacologically inert preparation prescribed more for the mental relief of the patient than for its actual effect on a disorder” – Merriam-Webster Medical Dictionary Everyone has heard of placebos, but have we ever wondered ...
Ismawi, Hidayatul Radziah
core  

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Secukinumab in Giant Cell Arteritis: An Italian Multicenter Cohort Study

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in patients with giant cell arteritis (GCA). Methods This multicenter retrospective study included patients with GCA who received secukinumab at 14 Italian centers with at least six months of follow‐up.
Luca Iorio, Federica Davanzo, Caterina Ricordi, Milena Bond, Ruggiero Mascolo, Jacopo Mora, Alessandro Tomelleri, Angelo Fassio, Francesca Cuzzocrea, Sara Monti, Edoardo Conticini, Fabiola Atzeni, Paolo Delvino, Carlotta Nannini, Augusta Ortolan, Francesco Pollastri, Ester Vivaldelli, Chiara Marvisi, Paola Toniati, Antonio Brucato, Alessandra Milanesi, Francesca Regola, Enrico Tombetti, Lorenzo Dagna, Roberta Ramonda, Christian Dejaco, Luca Quartuccio, Carlo Salvarani, Roberto Padoan   +28 more
wiley   +1 more source

Placebo effects on the neurologic pain signature: A meta-analysis of individual participant functional magnetic resonance imaging data

, 2018
Importance Placebo effects reduce pain and contribute to clinical analgesia, but after decades of research, it remains unclear whether placebo treatments mainly affect nociceptive processes or other processes associated with pain evaluation.Objective We ...
Leknes, S., Schenk, L., Benedetti, F., Zunhammer, M., Choi, J., Büchel, C., Kaptchuk, T., Müllner-Huber, A., Wager, T., Kong, J., Wrobel, N., Ellingsen, D., Kirsch, I., Lamm, C., Lui, F., Schmid, J., Theysohn, N., Colloca, L., Tracey, I., Porro, C., Zeidan, F., Duzzi, D., Gollub, R., Kessner, S., Rütgen, M., Eippert, F. ; https://orcid.org/, Bingel, U., Elsenbruch, S., Geuter, S., Atlas, L.   +29 more
core   +1 more source

Real‐World Safety of Concomitant Colchicine and Statin Therapy

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the risk of clinically meaningful muscle‐ and liver‐related outcomes associated with concomitant colchicine–statin therapy in a real‐world setting, and to determine whether concomitant therapy increases the incidence of toxicity compared with either agent alone.
Roni Meidan, Ranel Loutati, Dan Caspi, Ori Elkayam, Ran Abuhasira, Tali Eviatar   +5 more
wiley   +1 more source

Constructing the placebo effect in the placebo wars: What is the way ahead?

, 2012
The concept of placebo has had a long history in medicine, and has evolved over time with the introduction of randomized controlled trials for health treatments, the increasing research done around the psychotherapies, the development of complementary ...
Ridge, Damien T., Foot, D.
core  

Oral glucocorticoids added to ILD‐modifying therapy in systemic sclerosis‐associated interstitial lung disease: a target trial emulation study from the EUSTAR database.

Arthritis Care &Research, Accepted Article.
Objectives We aimed to estimate whether adding oral glucocorticoids to ILD‐modifying therapy improves 12‐month lung outcomes in systemic sclerosis‐associated interstitial lung disease (SSc‐ILD). Methods We emulated a target trial using the EUSTAR database.
Zubeyir Salis, Simona Truglia, Oliver Distler, Gábor Kumánovics, Gianluca Moroncini, David Launay, Silvia Bellando‐Randone, Gonçalo Boleto, Nicoletta Del Papa, Ana Maria Gheorghiu, Duygu Temiz Karadag, Zguro Batalov, Gabriella Szucs, Michele Iudici, The EUSTAR collaborators   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source