Results 111 to 120 of about 8,509,826 (346)

Do cultures influence placebo response?

Acta Psychiatrica Scandinavica, 2015
Individuals are born in, work in and live in cultures, which have a profound effect on their lives and functioning. Cultures determine cognitive schema and also how individuals express and deal with distress – whether it is physical or emotional ...
D. Bhugra, A. Ventriglio
semanticscholar   +1 more source

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

Advanced Science, EarlyView.
In this study, saponin‐coated silica@gold nanocarriers responsive to NIR radiation is developed to enhance intratympanic drug delivery for cisplatin‐induced hearing loss (CIHL) treatment. The biocompatibility and oto‐protective properties are validated both in vitro and in vivo.
Rawand A. Mustafa, Jiali Wang, Mengzhao Xun, Jessica M. Rosenholm, Wuqing Wang, Yilai Shu, Hongbo Zhang   +6 more
wiley   +1 more source

Repeated transcranial direct current stimulation (tDCS) in nondepressed reduces levels of reported negative affects from daily stressors [PDF]

arXiv, 2015
Negative emotional responses to the daily life stresses have cumulative effects which, in turn, impose wide-ranging negative constraints on emotional well being and neurocognitive performance (Kalueff:2007cp, Charles:2013eq, Nadler:2010hk). Crucial cognitive functions such as memory and problem solving, as well more short term emotional responses (e.g.,
arxiv  

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Enhancing single-arm phase II trials by inclusion of matched control patients [PDF]

arXiv, 2020
When a novel treatment has successfully passed phase I, different options to design subsequent phase II trials are available. One approach is a single-arm trial, comparing the response rate in the intervention group against a fixed proportion. Another alternative is to conduct a randomized phase II trial, comparing the new treatment with placebo or the
arxiv  

Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng, Xin Yang, Jiani Sun, Ximing Ran, Dan Zhou, Mingming Ye, Li Wen, Ruirui Wang, Miaoxin Chen   +8 more
wiley   +1 more source

Adaptive multicenter designs for continuous response clinical trials in the presence of an unknown sensitive subgroup [PDF]

arXiv, 2018
The partial effectiveness of drugs is of importance to the pharmaceutical industry. Randomized controlled trials (RCTs) assuming the existence of a subgroup sensitive to the treatment are already used. These designs, however, are available only if there is a known marker for identifying subjects in the subgroup.
arxiv  

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Inference for Synthetic Control Methods with Multiple Treated Units [PDF]

arXiv, 2019
Although the Synthetic Control Method (SCM) is now widely applied, its most commonly-used inference method, placebo test, is often problematic, especially when the treatment is not uniquely assigned. This paper discuss the problems with the placebo test under multivariate treatment case.
arxiv  

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Patients with active rheumatoid arthritis (RA) despite treatment with biologic disease-modifying antirheumatic drug (bDMARD) therapy need treatment options. Objective To evaluate the effects of filgotinib vs placebo on the signs and symptoms
M. Genovese, K. Kalunian, J. Gottenberg, N. Mozaffarian, B. Bartok, F. Matzkies, Jie Gao, Ying Guo, Chantal Tasset, J. Sundy, K. de Vlam, D. Walker, T. Takeuchi   +12 more
semanticscholar   +1 more source