Results 131 to 140 of about 8,509,826 (346)
BMC Medical Research Methodology, 2009 Background Assumptions underlying placebo controlled trials include that the placebo effect impacts on all study arms equally, and that treatment effects are additional to the placebo effect.
Bone Kerry M +3 more
doaj +1 more source
Gerontology, 2014 Predictors of the placebo response (PR) in randomized controlled trials (RCT) have been searched for ever since RCT have become the standard for testing novel therapies and age and gender are routinely documented data in all trials irrespective of the ...
K. Weimer, L. Colloca, P. Enck
semanticscholar +1 more source
Advanced Science, EarlyView.New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang +10 more
wiley +1 more source
Gamma oscillations and application of 40‐Hz audiovisual stimulation to improve brain function
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Audiovisual stimulation, such as auditory stimulation, light stimulation, and audiovisual combined stimulation, as a non‐invasive stimulation, which can induce gamma oscillation, has received increased attention in recent years, and it has been preliminarily applied in the clinical rehabilitation of brain dysfunctions, such as ...
Xixi Chen +6 more
wiley +1 more source
Novel study designs to investigate the placebo response
BMC Medical Research Methodology, 2011 Background Investigating the size and mechanisms of the placebo response in clinical trials have relied on experimental procedures that simulate the double-blind randomized placebo-controlled design.
Klosterhalfen Sibylle +2 more
doaj +1 more source
Efficient, Doubly Robust Estimation of the Effect of Dose Switching for Switchers in a Randomised Clinical Trial [PDF]
arXiv, 2020 Motivated by a clinical trial conducted by Janssen Pharmaceuticals in which a flexible dosing regimen is compared to placebo, we evaluate how switchers in the treatment arm (i.e., patients who were switched to the higher dose) would have fared had they been kept on the low dose.
arxiv
Improving Adult Vision Through Pathway‐Specific Training in Augmented Reality
Advanced Science, EarlyView.Traditional perceptual training approaches are limited by stimulus specificity, treatment efficacy, and patient compliance. A novel altered reality (AR) method is developed to enhance pathway‐specific functions in human adults while performing everyday activities.
Yige Gao +4 more
wiley +1 more source
Business Strategy and the Environment, Volume 32, Issue 1, Page 484-498, January 2023., 2023 Abstract This study examines whether and how outward foreign direct investment (OFDI) affects firms' domestic environmental performance. We use both the reverse knowledge transfer and resource crowding perspectives to predict the association. Using a sample of Chinese firms, we find that firms' environmental performance improves after the initiation of
Wenbin Long +3 more
wiley +1 more source
Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism
Advanced Science, EarlyView.Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley +1 more source
Equivalence of regression curves sharing common parameters [PDF]
arXiv, 2019 In clinical trials the comparison of two different populations is a frequently addressed problem. Non-linear (parametric) regression models are commonly used to describe the relationship between covariates as the dose and a response variable in the two groups.
arxiv