Results 241 to 250 of about 648,282 (342)

Dynamic Nature of the Placebo Response

, 2010
Steven Z. George, Michael E. Robinson
openalex   +1 more source

Patient‐Reported Outcomes and the Association With Clinical Response in Patients With Active Psoriatic Arthritis Treated With Golimumab: Findings Through 2 Years of a Phase III, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Trial [PDF]

, 2013
Arthur Kavanaugh, Iain B. McInnes, Gerald G. Krueger, Dafna D. Gladman, Anna Beutler, T. Gathany, M. Mack, Neeta Tandon, Chenglong Han, Philip J. Mease   +9 more
openalex   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Main factors associated with variability in the assessment of the objective response rate. A re‐analysis of the PHEREXA phase 3 clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele, Tommaso Giovagnoli, Pierluigi Navarra, Cinzia Dello Russo   +3 more
wiley   +1 more source

The placebo response

Complementary Therapies in Medicine, 2004
openaire   +2 more sources

Attenuation of Cardiovascular Responses to Direct Laryngoscopy and Intubation-A Comparative Study Between iv Bolus Fentanyl, Lignocaine and Placebo(NS).

, 2012
Gurulingappa, Md Asif Aleem, Muragesh Awati, S Adarsh   +3 more
openalex   +2 more sources

Study protocol: A multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study. [PDF]

, 2017
Jagdeep Nanchahal, Catherine Ball, Jennifer B. Swettenham, Susan Dutton, Vicki S Barber, Joanna Black, Bethan Copsey, Melina Dritsaki, Peter C. Taylor, Alastair Gray, Marc Feldmann, Sarah E Lamb   +11 more
openalex   +1 more source

Research Interviews in Historical Practice

Berichte zur Wissenschaftsgeschichte, EarlyView.
A key difference between collecting life stories and doing research interviews is the role of the interviewer. While training in oral history may focus on using standard scripts to take a life story, research interviews are motivated by specific questions that arise from particular historical projects and are often not primarily focused on the ...
Lara Keuck, Soraya de Chadarevian
wiley   +1 more source

Disentangling the Effects of Firm‐Level Climate Risk and Capital Market Signalling: Evidence From Stock Price Informativeness

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines the impact of firm‐level climate risk on stock price informativeness (SPI) through the integrated lens of stakeholder–shareholder theory. Using a global unbalanced panel of 73,770 firm‐year observations across 38 countries (2000–2020), we find that higher carbon emissions significantly reduce SPI, reflecting increased ...
Rawinder Kaur, Frank Kwabi, Wansu Hu, Samuel Fulgence, Neil Lancastle   +4 more
wiley   +1 more source

Regulation Through Revelation: The Effect of Pollution Monitoring on Labour Demand

Business Strategy and the Environment, EarlyView.
ABSTRACT This paper investigates how manufacturing firms respond to a real‐time pollution monitoring programme, with a focus on the implication for employment. Contrary to the conventional expectation that environmental regulations negatively impact business, the findings reveal that enhanced pollution monitoring has a significant and robust positive ...
Tong Zhu, Andreas Löschel
wiley   +1 more source