Results 81 to 90 of about 639,786 (193)

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Hauer, Daniela, Kilger, Erich, Schelling, Gustav, Schopp, Mirjam, Strewe, Claudia, Toth, Roland, Weis, Florian   +9 more
core   +1 more source

Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]

, 2017
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K., Mantravadi, Santhi, Ogdie, Alexis   +2 more
core   +2 more sources

Is placebo analgesia for heat pain a sensory effect? An exploratory study on minimizing the influence of response bias

Neurobiology of Pain, 2019
We explored the ongoing question of whether placebo analgesia alters afferent nociceptive processing in a novel paradigm designed to minimize the role of response bias in placebo measurement.
Laura K. Case, Claire M. Laubacher, Emily A. Richards, Matthew Grossman, Lauren Y. Atlas, Scott Parker, M. Catherine Bushnell   +6 more
doaj   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony, Holz, Olaf, Janicki, Stanislawa, Jörres, Rudolf A., Kanniess, Frank, Magnussen, Helgo, Richter, Kai, Simpson, Kathy J., Tal-Singer, Ruth, Vessey, Rupert S. J.   +9 more
core   +1 more source

Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping

Osteoarthritis and Cartilage Open
Objective: This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA.
Tommy Kok Annfeldt, Elisabeth Ginnerup-Nielsen, Eva Elisabeth Wæhrens, Lene Vase, Lars Erik Kristensen, Tanja Schjødt Jørgensen   +5 more
doaj   +1 more source

Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial

BMC Medical Research Methodology, 2009
Background Assumptions underlying placebo controlled trials include that the placebo effect impacts on all study arms equally, and that treatment effects are additional to the placebo effect.
Bone Kerry M, van Die M Diana, Burger Henry G, Teede Helena J   +3 more
doaj   +1 more source

Editorial: Placebo Effect in Pain and Pain Treatment

Frontiers in Pain Research, 2022
Michael H. Bernstein, Charlotte Blease, Lene Vase   +2 more
doaj   +1 more source

Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials

Journal of Pain Research, 2015
Roy Freeman,1 Birol Emir,2 Bruce Parsons2 1Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Pfizer Inc, New York, NY, USABackground: Greater understanding of factors associated ...
Freeman R, Emir B, Parsons B
doaj  

Gut Akkermansia muciniphila, Prevotellaceae, and Enterobacteriaceae spp. as Possible Markers in Women-Related Nutritional and Clinical Trials: Familial Mediterranean Fever Disease

Women's Health Reports
Background: Studies have shown that the gut microbiota of healthy men and men with familial Mediterranean fever (FMF) disease respond differently to placebo.
Astghik Pepoyan
doaj   +1 more source

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source