Results 61 to 70 of about 253,251 (305)

Early onset preeclampsia is characterized by altered placental lipid metabolism and a premature increase in circulating FABP4 [PDF]

, 2010
Preeclampsia is a pregnancy-associated disorder that manifests as a sudden increase in maternal blood pressure accompanied by proteinuria. Because the placenta is a key organ in preeclampsia, we used proteomic and lipidomic analyses to compare placentae ...
Aaron Booy, Delfina Siroen, Gilles Lajoie, Jennifer Ballard, Nicholas Carruthers, Victor H. Han   +5 more
core   +1 more source

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Locus-specific DNA methylation prediction in cord blood and placenta

Epigenetics, 2019
DNA methylation is known to be responsive to prenatal exposures, which may be a part of the mechanism linking early developmental exposures to future chronic diseases. Many studies use blood to measure DNA methylation, yet we know that DNA methylation is
Baoshan Ma, Catherine Allard, Luigi Bouchard, Patrice Perron, Murray A. Mittleman, Marie-France Hivert, Liming Liang   +6 more
doaj   +1 more source

Neonatal foal death due to infection with equine arteritis virus in Belgium [PDF]

, 2009
This case report describes a small outbreak of neonatal foal death in Belgium due to infection with equine arteritis virus (EAV). The outbreak started with one foal suffering from acute dyspnea four days after birth.
Chiers, Koen, Ducatelle, Richard, Govaere, Jan, Gryspeerdt, Annick, Nauwynck, Hans, Van de Walle, Gerlinde, Vercauteren, Griet   +6 more
core  

Achieving the Millennium Development Goal of reducing maternal mortality in rural Africa: an experience from Burundi. [PDF]

, 2012
OBJECTIVES: To estimate the reduction in maternal mortality associated with the emergency obstetric care provided by Médecins Sans Frontières (MSF) and to compare this to the fifth Millennium Development Goal of reducing maternal mortality.
Baskett, Campbell, Filippi, Fournier, Graham, Kongnyuy, Li, Maine, Mantel, Murray, Pattinson, Paxton, Penney, Prual, Ronsmans, Say, UNICEF/WHO/UNFPA, Waterstone, WHO, Zachariah   +19 more
core   +2 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Alteration of placental haemostatic mechanisms in idiopathic intrauterine growth restriction

Universitas Scientiarum, 2012
Intrauterine growth restriction is a complication of pregnancy with a high probability of perinatal morbidity and mortality. It appears tobe caused by abnormal development of placental vasculature.
Jaime Eduardo Bernal Villegas, Martha Cecilia Bermudéz de Rincon, Mercedes Olaya, Alejandra Espinosa, Paola Andrea Ayala-Ramírez, Reggie García-Robles, Juan Diego Rojas   +6 more
doaj  

The placenta is the center of the chronic disease universe [PDF]

American Journal of Obstetrics and Gynecology, 2015
(Am J Obstet Gynecol 2015;213(suppl):S14–S20) This review article explores the potential role of the placenta in the development of chronic diseases later in life. It discusses studies reporting an inverse relationship between birthweight and chronic disease, leading to a better understanding of health and longevity in offspring.
Kent L, Thornburg, Nicole, Marshall
openaire   +2 more sources

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source