Maternal Cardiovascular Impairment in Pregnancies Complicated by Severe Fetal Growth Restriction [PDF]
, 2012 —Fetal growth restriction and preeclampsia are both conditions of placental etiology and associated to increased risk for the long-term development of cardiovascular disease in the mother. At presentation, preeclampsia is associated with maternal global
Liberati, M +3 more
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Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Reproductive Biology and Endocrinology, 2009 Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg +7 more
doaj +1 more source
Circulating soluble endoglin and placental abruption [PDF]
Prenatal Diagnosis, 2008 AbstractObjectiveOur objective was to investigate whether serum concentrations of a novel anti‐angiogenic factor, soluble endoglin (sEng), could predict placental abruption.MethodsIn a nested case–control study of nulliparous pregnancies, we examined levels of sEng in serum collected prospectively from 31 women who later developed placental abruption ...
Caroline, Signore +6 more
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Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial
Taiwanese Journal of Obstetrics & Gynecology, 2018 Objective: Intrauterine growth restriction (IUGR) is one of the most serious complications of pregnancy. Up to date, there is no evidence of achieving antenatal treatment of IUGR with abnormal placentation.
Mohammed Maged +3 more
doaj +1 more source
Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
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Prenatal endotoxemia and placental drug transport in the mouse: placental size-specific effects. [PDF]
PLoS ONE, 2013 Lipopolysaccharide (LPS) in high doses inhibits placental multidrug resistance P-glycoprotein (P-gp--Abcb1a/b) and breast cancer resistance protein (BCRP--Abcg2).
Enrrico Bloise +6 more
doaj +1 more source
A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]
, 2012 Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank +4 more
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A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction. [PDF]
PLoS Computational Biology, 2014 Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood flow redistribution in order to maintain delivery of oxygenated blood to the brain.
Patricia Garcia-Canadilla +7 more
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MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]
, 2016 PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet +6 more
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Placental compliance during fetal extracorporeal circulation [PDF]
Journal of Applied Physiology, 2001 The fetus requires large amounts of volume when weaning from cardiac bypass. This suggests that placental vasculature can act as a large capacitor in the fetal circulation. To assess placental compliance of fetal lambs, seven isolated in situ lamb placentas were placed on extracorporeal circulation.
R S, Assad, F Y, Lee, F L, Hanley
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