Results 221 to 230 of about 194,763 (288)

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Glycaemic Management and Pregnancy Outcomes in HNF1A‐MODY

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Birthweight of HNF1A‐affected offspring is largely similar to the background population with rarely reported cases of large for gestational age (LGA) and neonatal hypoglycaemia (NH). Conventional clinical management of pre‐gestational diabetes appears to be sufficient in managing HNF1A‐affected women in pregnancy.
M. T. Crowley, P. McCluskey, N. Ng, B. Sanchez‐Lechuga, A. Fleming, M. Hatunic, B. Kinsley, S. Bacon, K. Colclough, M. Kennelly, M. M. Byrne   +10 more
wiley   +1 more source

Metformin Use During Pregnancy and Early‐Life Nutritional Status: A Systematic Review of Randomized Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aims Metformin is increasingly used to treat gestational diabetes mellitus and other insulin‐resistant conditions during pregnancy. Because it crosses the placenta, concerns remain regarding its potential effects on offspring growth and metabolic programming.
Otilia Perichart‐Perera, Larissa Hernández‐Hernández, Ameyalli M. Rodríguez‐Cano   +2 more
wiley   +1 more source

Ectopic pregnancy in a horse

Equine Veterinary Education, EarlyView.
Summary An ectopic fetus was discovered in the abdominal cavity of a 21‐year‐old Haflinger mare, which was referred to an equine clinic because of colic symptoms. The mare had been inseminated 3 years previously and was confirmed pregnant at 90 days.
M. S. Swoboda, A. K. Rötting, H. Sieme, J. Sielhorst   +3 more
wiley   +1 more source

DLK1: A Novel Biomarker of Placental Insufficiency in Stillbirth and Live Birth. [PDF]

Am J Perinatol
Page JM, Allshouse AA, Gaffney JE, Roberts VHJ, Thorsten V, Gibbins KJ, Dudley DJ, Saade G, Goldenberg RL, Stoll BJ, Hogue CJ, Bukowski R, Parker C, Conway D, Reddy UM, Varner MW, Frias AE, Silver RM.   +17 more
europepmc   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Perioperative von Willebrand Factor and Factor VIII Kinetics in von Willebrand Disease Patients Treated With Different Clotting Factor Concentrates

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with von Willebrand disease (VWD) undergoing surgery require von Willebrand factor (VWF) and factor VIII (FVIII) supplementation for adequate haemostasis. Plasma‐derived clotting factor concentrates differ in their VWF:FVIII activity ratios: high‐ratio product (HRP, 10:1), intermediate‐ratio product (IRP, 2.4:1), and low ...
Zoë A. Gras, Geoffrey Z. L. Kuppens, Roger E. G. Schutgens   +2 more
wiley   +1 more source

Pregnancy outcomes following exposure to galcanezumab: Analysis of cases from the galcanezumab clinical trials and postmarketing database

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study was conducted to describe pregnancy outcomes reported following maternal or paternal exposure to galcanezumab in clinical trials and postmarketing surveillance. Background Galcanezumab is a calcitonin gene‐related peptide‐inhibiting monoclonal antibody indicated for the preventive treatment of migraine.
Irene Boz, Jan Lewis Brandes, Christopher Robinson, Maria Fernanda Scantamburlo Fernandes, Sarah Lipsius, LaRonda Morford, Enemona Emmanuel Adaji, Anaclara Prada Jardim, Holland C. Detke   +8 more
wiley   +1 more source

Ethylenediaminetetraacetic Acid and Other Dentine Bioactive Molecule‐Releasing Agents for Regenerative Endodontic Procedures: A Systematic Review

International Endodontic Journal, EarlyView.
ABSTRACT Background The bioactive molecules released from dentine are key to stem‐cell recruitment, proliferation and differentiation in regenerative endodontics. However, there is limited and conflicting information regarding current and potential agents for releasing dentine bioactive molecules for regenerative endodontic procedures.
Arwa Al‐Maswary, Xiaoxuan Deng, Haizal M. Hussaini, Lara T. Friedlander, Paul R. Cooper   +4 more
wiley   +1 more source

Cosmetic Dermatology in Pregnancy and Lactation: A Risk–Benefit Framework for Clinical Practice

International Journal of Dermatology, EarlyView.
Summary of the safety profile of common cosmetic dermatology interventions during pregnancy and lactation. ABSTRACT Cosmetic dermatologic products and procedures are increasingly utilized by women of reproductive age, including those who are pregnant or lactating.
Timea Kovacs, Umer Nadir, Michael Goldenberg, Thomas E. Rohrer, Deirdre Hooper, George M. Jeha, Stanislav N. Tolkachjov   +6 more
wiley   +1 more source