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Wilkin, Paul
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The Fetal Response to Chronic Placental Insufficiency
Seminars in Perinatology, 2008Fetal growth restriction is most commonly caused by failure of the placenta to meet the increasing demands for oxygen and substrate of the developing fetus, resulting in common fetal compensatory responses. Understanding these responses is helpful in developing a management strategy that will optimize pregnancy outcome.
Mark G Neerhof, Larry G Thaete
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The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review [PDF]
Placental insufficiency affects about 10% of pregnancies and can lead to pre-eclampsia, fetal growth restriction, and preterm birth. Despite significant advances in early prediction and prevention of preterm pre-eclampsia with aspirin, the effects of ...
Rolnik Dl +2 more
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Study of mitochondrial function in placental insufficiency [PDF]
INTRODUCTION: It has been suggested that mitochondria play a crucial role in sustaining pregnancy and foetal growth. The aim of the study was to assess the influence of mitochondrial functions and genetics on placental insufficiency diseases.
Geraldine Gascoin +2 more
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Placental insufficiency is a major problem worldwide for both mothers and babies. However, we have demonstrated in a review of the biomedical literature, that both the terminology used to describe, and techniques used to measure suboptimal placental ...
Manu Vatish, Stephen Kennedy
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Nanomedicines: An approach to treat placental insufficiency and the current challenges [PDF]
INTRODUCTION: Preeclampsia and fetal growth restriction are common pregnancy complications that significantly impact perinatal health and offspring development later in life.
Schiffelers, R +4 more
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Placental insufficiency and postmaturity
European Journal of Obstetrics & Gynecology and Reproductive Biology, 1975Full placental development and functioning are achieved around the 5th month of gestation. Thereafter, until birth, signs of gradual placental aging are observed which are partly compensated by an increase in trophoblastic surface area to maintain adequate fetal oxygen and nutrient supply (Krantz and Kubli, 1967; Hellegers, 1969).
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Elevated circulating and placental SPINT2 is associated with placental insufficiency
Placenta, 2021No description ...
Murphy, Ciara +13 more
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Placental insufficiency and its consequences
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2003Placental insufficiency is a process leading to progressive deterioration in placental function and a decrease in transplacental transfer of oxygen and nutrients to the fetus. The resulting fetal hypoxemia is the major stimulus involved in the reduction in fetal growth as an attempt to reduce metabolic demands by the growing fetus.
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Placental Gene Expression in a Rat ‘Model’ of Placental Insufficiency
Placenta, 2010Placental insufficiency is a major factor associated with pregnancy complications such as miscarriages, intrauterine growth restriction and pre-eclampsia. Recent studies have identified the Brown Norway (BN) rat as a natural 'model' of placental insufficiency associated with decreased trophoblast remodeling of maternal uterine arteries.Genetic pathways
R, Goyal +3 more
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