Results 31 to 40 of about 96,077 (207)

Progesterone receptors in the human placenta: Expression, signalling characteristics and functional relevance [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The human placenta is a transient life sustaining organ which is responsible for mediating all the physiological exchanges between the mother and the fetus.
Zachariades, Elena
core   +7 more sources

Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways

Antioxidants, 2021
Preeclampsia, a hypertensive disorder occurring during pregnancy, is characterized by excessive oxidative stress and trophoblast dysfunction with dysregulation of soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) production ...
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi   +7 more
doaj   +1 more source

Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus

Сахарный диабет, 2020
Рathogenesis of the chronic placental insufficiency is largely determined by the type of diabetes mellitus and the degree of its compensation. Trophic function failure of placenta changes its hormonal activity, formation of respiratory disorders and ...
Tatyana G. Tral, Gulrukhsor Kh. Tolibova, Ekaterina V. Musina, Maria I. Yarmolinskaya   +3 more
doaj   +1 more source

Multiple types of exogenous microparticles coexist in the early human decidua and placental villi

Environment International
Maternal exposure to exogenous microparticles (EMP) during pregnancy is associated with multiple adverse birth outcomes, yet evidence for its accumulation in early placental tissues remains limited.
Yudong Feng, Di Wu, Quanquan Guan, Qing Wang, Qing Xu, Ruijie Li, Chen Tu, Xiangliang Pan, Jamie L. Inman, Antoine M. Snijders, Bo Hang, Willie J.G.M. Peijnenburg, Yongming Luo, Yankai Xia   +13 more
doaj   +1 more source

Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles

Scientific Reports, 2017
In severe early-onset preeclampsia (sPE) the placenta releases soluble angiogenesis-regulating proteins, trophoblast-derived fragments, and extracellular vesicles (EVs). Their relative importance in disease pathogenesis is not presently understood.
Michelle O’Brien, Dora Baczyk, John C. Kingdom   +2 more
doaj   +1 more source

Disorder of the structure and vascularization of the villi of placenta at the preeclampsia [PDF]

Гинекология, 2018
Preeclampsia is considered one of the most serious diseases of pregnancy and cause serious complications in the mother and fetus. The emergence and development of preeclampsia is due to the violation of placental processes.
A I Shchegolev, U N Tumanova, V M Lyapin
doaj   +1 more source

Soluble Flt-1 and PlGF: new markers of early pregnancy loss? [PDF]

, 2011
Recent data have indicated a relationship between placental oxygen and angiogenic protein levels in the first trimester of normal pregnancies. Our objective was to investigate if maternal serum levels of angiogenic factors Soluble vascular endothelial ...
Michelle Swer, Muttukrishna, S, Suri, S, Jurkovic, Davor, Jamil, Amna, Swer, Michelle, Suri, Sangeeta, Sangeeta Suri, Jauniaux, E, Gangooly, Subrata, Gangooly, S, Calleja-Agius, Jean, Jamil, A, Amna Jamil, Ludlow, H, Muttukrishna, Shanthi, Jurkovic, D, Helen Ludlow, Davor Jurkovic, Calleja-Agius, J, Eric Jauniaux, Subrata Gangooly, Swer, M, Jean Calleja-Agius, Jauniaux, Eric R.M., Ludlow, Helen, Shanthi Muttukrishna   +26 more
core   +2 more sources

Morphometric image analysis of placental C-type lectin domain family 2, member D (CLEC2D) immuno-expression in HIV associated pre-eclampsia

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2019
Objective: C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses.
Deneshree Varaden, Jagidesa Moodley, Onankoy A. Onyangunga, Thajasvarie Naicker   +3 more
doaj   +1 more source

Hofbauer Cells Spread Listeria monocytogenes among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors

mBio, 2021
Pregnant women are highly susceptible to infection by the bacterial pathogen Listeria monocytogenes, leading to miscarriage, premature birth, and neonatal infection. L. monocytogenes is thought to breach the placental barrier by infecting trophoblasts at
Siavash Azari, Lauren J. Johnson, Amy Webb, Sophia M. Kozlowski, Xiaoli Zhang, Kara Rood, Amal Amer, Stephanie Seveau   +7 more
doaj   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source