Plakoglobin is a mechanoresponsive regulator of naive pluripotency [PDF]
Nature Communications, 2023 Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-implantation ...
Timo N. Kohler +17 more
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Plakoglobin: Role in Tumorigenesis and Metastasis [PDF]
International Journal of Cell Biology, 2012 Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion.
Manijeh Pasdar
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Illuminating Cardiac Remodeling: Insights From [18F]‐Fluorodeoxyglucose Positron Emission Tomography Imaging in Plakoglobin‐Associated Arrhythmogenic Cardiomyopathy [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease, which presents with arrhythmias and sudden cardiac death, along with progressive cardiac remodeling and myocardial inflammation.
Tatjana Williams +11 more
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The Impact of EPAC2-Associated Junction Plakoglobin on Respiratory Syncytial Virus Infection [PDF]
VirusesRespiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants, young children, and immunocompromised individuals. Currently, FDA-approved monoclonal antibody therapies are limited to infants and young children with
Chaitra A. Takle +10 more
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Plakoglobin does not participate in endothelial barrier stabilization mediated by cAMP [PDF]
Scientific ReportsCritical for maintenance of endothelial barrier is the remodeling of the actin cytoskeleton and the precise control of junctional integrity. Plakoglobin (PG) is a structural and signaling protein involved in vascular permeability regulation together with
Ibrahim Hamad +5 more
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Differential effect of plakoglobin in restoring the tumor suppressor activities of p53-R273H vs. p53-R175H mutants. [PDF]
PLoS ONEThe six most common missense mutations in the DNA binding domain of p53 are known as "hot spots" and include two of the most frequently occurring p53 mutations (p53-R175H and p53-R273H).
Chu Shiun Lo +4 more
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Biomarker Research, 2017 Background Circulating tumor cells (CTCs) are linked to metastatic relapse and are regarded as a prognostic marker for human cancer. High expression of plakoglobin, a cell adhesion protein, within the primary tumor is positively associated with CTC ...
Shinichiro Kashiwagi +1 more
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SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells [PDF]
BMC Cell Biology, 2011 Background SOX4 is a developmental transcription factor that is required for differentiation and proliferation in multiple tissues. SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is still not well ...
Lai Yu-Heng +7 more
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DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway [PDF]
PLoS ONE, 2013 Desmoglein 3 (DSG3) is a component of the desmosome, which confers strong cell-cell adhesion. Previously, an oncogenic function of DSG3 has been found in head neck cancer (HNC).
Yin-ju Chen +2 more
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Plakoglobin Represses SATB1 Expression and Decreases In Vitro Proliferation, Migration and Invasion [PDF]
PLoS ONE, 2013 Plakoglobin (γ-catenin) is a homolog of β-catenin with dual adhesive and signaling functions. Plakoglobin participates in cell-cell adhesion as a component of the adherens junction and desmosomes whereas its signaling function is mediated by its ...
Manijeh Pasdar
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