Adipocyte‐specific ablation of plakoglobin in mice does not affect adiposity but results in sexual‐dimorphic effects on weight gain [PDF]
Physiological ReportsThe main transcriptional coactivator of the WNT pathway, β‐catenin, is a well‐established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete.
Frederic Abou Azar +6 more
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Cell-cell contact preserves cell viability via plakoglobin. [PDF]
PLoS ONE, 2011 Control over cell viability is a fundamental property underlying numerous physiological processes. Cell spreading on a substrate was previously demonstrated to be a major factor in determining the viability of individual cells. In multicellular organisms,
Qi Wei +2 more
doaj +5 more sources
Plakoglobin is a mechanoresponsive regulator of naive pluripotency [PDF]
Nature Communications, 2023 Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-implantation ...
Timo N. Kohler +17 more
doaj +7 more sources
DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway. [PDF]
PLoS ONE, 2013 Desmoglein 3 (DSG3) is a component of the desmosome, which confers strong cell-cell adhesion. Previously, an oncogenic function of DSG3 has been found in head neck cancer (HNC).
Yin-Ju Chen +10 more
doaj +3 more sources
Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion. [PDF]
PLoS ONE, 2013 Plakoglobin (γ-catenin) is a homolog of β-catenin with dual adhesive and signaling functions. Plakoglobin participates in cell-cell adhesion as a component of the adherens junction and desmosomes whereas its signaling function is mediated by its ...
Zackie Aktary, Manijeh Pasdar
doaj +3 more sources
Nature Communications, 2020 Insulin receptor signaling governs central physiological functions related to cell growth and metabolism. Here the authors use protein complex purification and super-resolution microscopy to show that insulin receptor activity requires association with ...
Yara Eid Mutlak +6 more
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Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma [PDF]
Cancer Communications, 2021 Background Increased hypoxia‐inducible factor 2α (HIF2α) activation is a common event in clear cell renal cell carcinoma (ccRCC) progression. However, the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated. We conducted this study
Ke Chen +15 more
doaj +2 more sources
Regulation of sonic hedgehog-
BMC Cancer, 2010 Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Eberhart Charles G +6 more
doaj +7 more sources
Differential effect of plakoglobin in restoring the tumor suppressor activities of p53-R273H vs. p53-R175H mutants. [PDF]
PLoS ONEThe six most common missense mutations in the DNA binding domain of p53 are known as "hot spots" and include two of the most frequently occurring p53 mutations (p53-R175H and p53-R273H).
Chu Shiun Lo +4 more
doaj +2 more sources
Illuminating Cardiac Remodeling: Insights From [18F]‐Fluorodeoxyglucose Positron Emission Tomography Imaging in Plakoglobin‐Associated Arrhythmogenic Cardiomyopathy [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease, which presents with arrhythmias and sudden cardiac death, along with progressive cardiac remodeling and myocardial inflammation.
Tatjana Williams +11 more
doaj +2 more sources