Results 91 to 100 of about 9,804 (231)
Naxos disease: from the origin to today
Orphanet Journal of Rare Diseases, 2018 Naxos disease, first described by Dr. Nikos Protonotarios and colleagues on the island of Naxos, Greece, is a special form of arrhythmogenic right ventricular dysplasia (ARVD).
Guo-Liang Li +2 more
doaj +1 more source
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source
Molecular Oncology, Volume 19, Issue 9, Page 2670-2685, September 2025.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
wiley +1 more source
Normalization of Naxos plakoglobin levels restores cardiac function in mice [PDF]
Journal of Clinical Investigation, 2015 Arrhythmogenic cardiomyopathy (AC) is associated with mutations in genes encoding intercalated disc proteins and ultimately results in sudden cardiac death. A subset of patients with AC have the autosomal recessive cardiocutaneous disorder Naxos disease, which is caused by a 2-base pair deletion in the plakoglobin-encoding gene JUP that results in a ...
Zhang, Zhiwei +13 more
openaire +4 more sources
Cardiac sarcoidosis with severe involvement of the right ventricle: a case report
Autopsy and Case Reports, 2015 We present the case of a patient who underwent cardiac transplantation with the diagnosis of idiopathic dilated cardiomyopathy. Once the explanted heart was examined, a type of granulomatous myocarditis compatible with cardiac sarcoidosis was observed ...
Weverton César Siqueira +6 more
doaj +1 more source
Force dependent biotinylation of myosin IIA by α-catenin tagged with a promiscuous biotin ligase. [PDF]
PLoS ONE, 2015 Tissues and organs undergo constant physical perturbations and individual cells must respond to mechanical forces to maintain tissue integrity. However, molecular interactions underlying mechano-transduction are not fully defined at cell-cell junctions ...
Shuji Ueda +4 more
doaj +1 more source
Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. [PDF]
, 2012 Protein turnover through cullin-3 is tightly regulated by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link cullin-3 to specific substrates for ubiquitylation.
Chen, Ju +3 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.Rs12472215 A>T mutation induces enhanced transcriptional inhibition of Foxo3 on ctnna2 in humans. Alterations in the Sirt1‐Foxo3/Ascl1‐ctnna2 axis and reduction of α‐N‐catenin are involved in a mouse model of PND. A decoy that disturbs the interaction between Foxo3 and ctnna2 prevents PND in mice (Created in BioRender. Deng, J. (2025), http://BioRender.
Zhixin Wu +12 more
wiley +1 more source
MedComm, Volume 6, Issue 5, May 2025.We identified four proteins (DSP, JUP, HRNR, and DDX6) that bind to amyloid‐beta (Aβ) oligomers derived from the brains of Alzheimer's disease (AD) patients. Among these four proteins, only the blockade of DEAD‐box helicase 6 (DDX6) in AD brain‐derived Aβ oligomers attenuated their neurotoxicity.
Xiaoxu Wang +10 more
wiley +1 more source
Cell Structure and Function, 2005 F9 teratocarcinoma cells in which beta-catenin and/or plakoglobin genes are knocked-out were generated and investigated in an effort to define the role of beta-catenin and plakoglobin in cell adhesion. Loss of beta-catenin expression only did not affect cadherin-mediated cell adhesion activity.
Yoshitaka, Fukunaga +5 more
openaire +3 more sources