Results 101 to 110 of about 9,804 (231)

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2009
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Babbage, Jane, Bangsow, Thorsten, Corada, Monica, Czupalla, Cathrin Jacqueline, Dejana, Elisabetta, Felici, Angelina, Fruttiger, Marcus, Gerhardt, Holger, Liebner, Stefan, Melchner, Harald von (Prof. Dr.), Plate, Karl H., Reis, Marco, Taddei, Andrea, Taketo, Makoto Mark, Wolburg, Hartwig   +14 more
core  

VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers [PDF]

, 2016
13 p.-6 fig.We have investigated the role of vascular-endothelial (VE)-cadherin in melanoma and breast cancer metastasis. We found that VE-cadherin is expressed in highly aggressive melanoma and breast cancer cell lines.
Bartolomé, Rubén Álvaro, Calviño, Eva, Casal, J. Ignacio, Escudero-Paniagua, B., Isern de Val, Soledad, Teixidó, Joaquín, Torres, Sofía   +6 more
core   +1 more source

Long‐term remission of Hailey–Hailey disease by Er:YAG ablative laser therapy

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 1038-1045, May 2025.
Upper left panel: Hailey–Hailey lesion at baseline, directly after, 6 weeks and 3 years after a single Er:YAG laser ablation. Long‐term remission was noted in 75/77 Hailey–Hailey plaques after a median follow‐up of 38 months. Upper right panel: Median quality of life scores at baseline, 6 weeks and 3 years after laser ablation with a significant ...
Marie‐Eline P. H. Debeuf, Kèvin Knoops, Carmen López‐Iglesias, Eline Lookermans, Patty J. Nelemans, Myrurgia Abdul Hamid, Michel van Geel, Antoni H. Gostynski, Peter M. Steijlen, Marieke C. Bolling, Valerie L. R. M. Verstraeten   +10 more
wiley   +1 more source

Diagnostic difficulties in a case of a female patient with pemphigus vulgaris

Przegląd Dermatologiczny, 2016
Introduction . Autoimmune blistering diseases are mediated by autoantibodies directed against structural proteins of the skin. Pemphigus vulgaris (PV) is the most common type of pemphigus.
Maria Weryńska-Kalemba, Agata Filipowska-Grońska, Kamila Zawadzińska-Halat, Karolina Filipowska, Jerzy Jarząb   +4 more
doaj   +1 more source

EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation

JCI Insight, 2023
Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options.
Maria Shoykhet, Orsela Dervishi, Philipp Menauer, Matthias Hiermaier, Sina Moztarzadeh, Colin Osterloh, Ralf J. Ludwig, Tatjana Williams, Brenda Gerull, Stefan Kääb, Sebastian Clauss, Dominik Schüttler, Jens Waschke, Sunil Yeruva   +13 more
doaj   +1 more source

Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy

The Journal of Physiology, Volume 603, Issue 7, Page 1959-1982, 31 March 2025.
Abstract figure legend Cardiac sympathetic neurons express desmoglein‐2 (DSG2) and harbour mutations in DSG2‐linked arrhythmogenic cardiomyopathy. DSG2 mutations affect sympathetic neuron biology (i.e. reduced axonal sprouting, irregular distribution of varicosities) and result in aberrant cardiac innervation.
Induja Perumal Vanaja, Arianna Scalco, Marco Ronfini, Anna Di Bona, Camilla Olianti, Stefania Rizzo, Stephen P. Chelko, Domenico Corrado, Leonardo Sacconi, Cristina Basso, Marco Mongillo, Tania Zaglia   +11 more
wiley   +1 more source

Plakoglobin‐dependent disruption of the desmosomal plaque in pemphigus vulgaris

Experimental Dermatology, 2007
Abstract:  We recently reported that the pathogenesis of pemphigus vulgaris (PV), an autoimmune blistering skin disorder, is driven by the accumulation of c‐Myc secondary to abrogation of plakoglobin (PG)‐mediated transcriptional c‐Myc suppression.
de Bruin, A., Caldelari, R., Williamson, L., Suter, M.M., Hunziker, T., Wyder, M., Muller, E.J.   +6 more
openaire   +4 more sources

Understanding host's response to staphylococcal scalded skin syndrome

Acta Paediatrica, Volume 114, Issue 2, Page 241-247, February 2025.
Abstract Aim The aim of this review was to summarise the current knowledge on host‐related factors that contribute to the development and severity of staphylococcal scalded skin syndrome (SSSS) in children. Methods A comprehensive assessment and analysis of the existing literature on SSSS clinical features, pathogenesis and susceptibility factors ...
Glykeria Rouva, Eleni Vergadi, Konstantinos Krasagakis, Emmanouil Galanakis   +3 more
wiley   +1 more source

Mechanical Property Changes in Breast Cancer Cells Induced by Stimulation with Macrophage Secretions in Vitro

Micromachines, 2019
The contribution of secretions from tumor-associated macrophage (TAM)-like cells to the stimulation of mechanical property changes in murine breast cancer cells was studied using an in vitro model system.
Hyonchol Kim, Kenta Ishibashi, Tomoko Okada, Chikashi Nakamura   +3 more
doaj   +1 more source

Nonischemic left ventricular scar and cardiac sudden death in the young [PDF]

, 2016
Nonischemic Left Ventricular Scar (NLVS) is a pattern of myocardial injury characterized by midventricular and/or subepicardial gadolinium hyper enhancement at cardiac magnetic resonance, in absence of significant coronary artery disease.
CERBELLI, BRUNA, CIALLELLA, Costantino, D'AMATI, Giulia, DE DOMINICIS, ENRICO, DI GIOIA, Cira Rosaria Tiziana, GIORDANO, Carla, PALMIERI, VINCENZO, PERLI, ELENA, PISANO, ANNALINDA, Poscolieri, Barbara, Zeppilli, Paolo   +10 more
core   +1 more source