Results 11 to 20 of about 9,804 (231)

Plakoglobin: Role in Tumorigenesis and Metastasis [PDF]

International Journal of Cell Biology, 2012
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion.
Zackie Aktary, Manijeh Pasdar
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Naxos Disease and Related Cardio-Cutaneous Syndromes [PDF]

JACC: Advances
Naxos disease is a rare autosomal recessive condition combining arrhythmogenic right ventricular cardiomyopathy, woolly hair, and palmoplantar keratoderma. The first identified causative variant was in the gene encoding the desmosomal protein plakoglobin.
Alexandros Protonotarios, MD, Angeliki Asimaki, Ph.D, Cristina Basso, MD, Zafeirenia Xylouri, MD, Emanuele Monda, MD, Ioannis Protonotarios, MD, Giulia Crisci, MD, Dominic JR. Abrahms, MMBS, MD, MBA, Aris Anastasakis, MD, Loizos Antoniades, MD, Athanasios Bakalakos, MD, Andreina Carbone, MD, Aman S. Coonar, MD, Juan Ramon Gimeno, MD, George Lazaros, MD, Stamatis Lerakis, MD, Luisa Mestroni, MD, George Papadopoulos, MD, Leandro Pecchia, MD, Francesca Romana Prandi, MD, Petros Syrris, MD, Julia Cadrin-Turigny, MD, Anargyros Vasilakis, MSc, Jeffrey E. Saffitz, MD, PhD, Stamatios Gaetano Thiene, MD, Perry M. Elliott, MD, Juan Pablo Kaski, MD, William J. McKenna, MD, Eduardo Bossone, MD, Giuseppe Limongelli, MD, Adalena Tsatsopoulou, MD   +30 more
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Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets [PDF]

Molecular Oncology, 2021
Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ‐catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microarray ...
Tanja Spethmann, Lukas Clemens Böckelmann, Vera Labitzky, Ann‐Kristin Ahlers, Jennifer Schröder‐Schwarz, Sarah Bonk, Ronald Simon, Guido Sauter, Hartwig Huland, Robert Kypta, Udo Schumacher, Tobias Lange   +11 more
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Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis.

PLoS ONE, 2012
To date, no plaque-derived blood biomarker is available to allow diagnosis, prognosis or monitoring of atherosclerotic vascular diseases. In this study, specimens of thrombendarterectomy material from carotid and iliac arteries were incubated in protein ...
Seraina Cooksley-Decasper, Hans Reiser, Daniela S Thommen, Barbara Biedermann, Michel Neidhart, Joanna Gawinecka, Gieri Cathomas, Fabian C Franzeck, Christophe Wyss, Roland Klingenberg, Paolo Nanni, Bernd Roschitzki, Christian Matter, Petra Wolint, Maximilian Y Emmert, Marc Husmann, Beatrice Amann-Vesti, Wilibald Maier, Steffen Gay, Thomas F Lüscher, Arnold von Eckardstein, Danielle Hof   +21 more
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The Impact of EPAC2-Associated Junction Plakoglobin on Respiratory Syncytial Virus Infection [PDF]

Viruses
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants, young children, and immunocompromised individuals. Currently, FDA-approved monoclonal antibody therapies are limited to infants and young children with
Chaitra A. Takle, Eun-Jin Choi, Eun Seok Choi, Devang Deepak, Kashish Khatkar, Jong Min Choi, Ke Zhang, Sung Yun Jung, Tian Wang, Wenzhe Wu, Xiaoyong Bao   +10 more
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Transcriptional deregulation by FOXM1–JUP signaling confers dual oncogenic drivers for pancreatic tumorigenesis and therapeutic resistance [PDF]

Cell Communication and Signaling
Purpose Junction plakoglobin (JUP/γ-catenin) is a dual-component cell adhesion molecule of adherens junctions and desmosomes, maintaining epithelial homeostasis while paradoxically involving oncogenic transformation.
Kailing Yang, Zhihong He, Tingting Jiang, Tian Cai, Xiaojia Li, Keping Xie   +5 more
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Plakoglobin does not participate in endothelial barrier stabilization mediated by cAMP [PDF]

Scientific Reports
Critical for maintenance of endothelial barrier is the remodeling of the actin cytoskeleton and the precise control of junctional integrity. Plakoglobin (PG) is a structural and signaling protein involved in vascular permeability regulation together with
Ibrahim Hamad, Sara Sepic, Sina Moztarzadeh, Alexander García-Ponce, Jens Waschke, Mariya Y. Radeva   +5 more
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Junction plakoglobin (JUP) [PDF]

Science-Business eXchange, 2014

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Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin

Frontiers in Immunology, 2019
Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
Dyah A. M. Oktarina, Dyah A. M. Oktarina, Ena Sokol, Duco Kramer, Marcel F. Jonkman, Hendri H. Pas   +5 more
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The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes [PDF]

The Journal of Cell Biology, 1997
The desmosome is a highly organized plasma membrane domain that couples intermediate filaments to the plasma membrane at regions of cell–cell adhesion. Desmosomes contain two classes of cadherins, desmogleins, and desmocollins, that bind to the cytoplasmic protein plakoglobin.
Andrew P. Kowalczyk, Elayne A. Bornslaeger, Jeffrey E. Borgwardt, H. Pałka, Avninder S. Dhaliwal, Connie M. Corcoran, Mitchell F. Denning, Kathleen J. Green   +7 more
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