Results 11 to 20 of about 5,949 (220)

Junction Plakoglobin - A Dual-Role Player in Cancer Biology. [PDF]

Int J Surg
Junction plakoglobin (JUP) is a critical cell adhesion molecule implicated in mediating cell-cell adhesion. Cancer, characterized by the loss of normal cellular regulation, results in unchecked proliferation and the breakdown of cell-cell junctions ...
Ding W, Sun J, Song S, Cui Y, Chen F, Yuan Q, Shang W.   +6 more
europepmc   +5 more sources

Generation of a CRISPR/Cas9-edited Plakoglobin (JUP) knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy

Stem Cell Research, 2023
Arrhythmogenic cardiomyopathy (ACM) represents the cardiac phenotype of Naxos disease, an autosomal recessive disease with an additional cutaneous phenotype.
Katharina Walz, Anna Janz, Eva Klopocki, Brenda Gerull   +3 more
doaj   +3 more sources

A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size

Nature Communications, 2020
Insulin receptor signaling governs central physiological functions related to cell growth and metabolism. Here the authors use protein complex purification and super-resolution microscopy to show that insulin receptor activity requires association with ...
Nitsan Dahan, Shenhav Cohen
exaly   +3 more sources

Ovarian Blood Sampling Identifies Junction Plakoglobin as a Novel Biomarker of Early Ovarian Cancer [PDF]

Frontiers in Oncology, 2020
Ovarian cancer is the most lethal gynecologic malignancy. Early detection would improve survival, but an effective diagnostic test does not exist. Novel biomarkers for early ovarian cancer diagnosis are therefore warranted.
Florian Weiland, Florian Weiland, Florian Weiland, Noor A. Lokman, Manuela Klingler-Hoffmann, Thomas Jobling, Andrew N. Stephens, Andrew N. Stephens, Karin Sundfeldt, Peter Hoffmann, Martin K. Oehler, Martin K. Oehler, Martin K. Oehler   +12 more
doaj   +3 more sources

Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes [PDF]

Frontiers in Physiology, 2020
Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as ...
Sunil Yeruva, Ellen Kempf, Desalegn Tadesse Egu, Heinrich Flaswinkel, Daniela Kugelmann, Jens Waschke   +5 more
doaj   +3 more sources

Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse [PDF]

The Journal of Physiology, Volume 602, Issue 18, Page 4409-4436, 15 September 2024.
Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex and increased AAS levels are associated with earlier and more severe manifestation of common cardiac conditions, such as atrial fibrillation, and rare ones, such as ...
Laura Sommerfeld, Andrew P. Holmes, Ting Yu, Christopher O’Shea, Deirdre M. Kavanagh, Jeremy A. Pike, Tom Wright, Fahima Syeda, Areej Aljehani, Tania Kew, Victor Roth Cardoso, S. Nashitha Kabir, Claire Hepburn, Priyanka Rajeev Menon, Sophie Broadway‐Stringer, Molly O’Reilly, Anika Witten, Lisa Fortmueller, Susanne Lutz, Alexandra Kulle, Georgios V. Gkoutos, Davor Pavlović, Wiebke Arlt, Gareth G. Lavery, Richard P. Steeds, Katja Gehmlich, Monika Stoll, Paulus Kirchhof, Larissa Fabritz   +28 more
semanticscholar   +3 more sources

Identification of p53-R175H Q167 and R248 as Residues Most Involved in Its Interaction with Plakoglobin

Re:GEN Open, 2023
Background: The conformational p53-R175H is the most frequently occurring p53 mutant in cancers and a focus of mutant p53 targeted therapies. Plakoglobin is a dual cell adhesion and signaling protein with tumor suppressor activity.
Chu Shiun Lo, Chu Shiun Lo, Sara Ibrahim Omar, Jinlan Chang, Blessing Bassey-Archibong, Jack A Tuszynski, Jack A Tuszynski, Nadia Jahroudi, Manijeh Pasdar   +8 more
doaj   +2 more sources

KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway

Breast Cancer Research, 2022
Background Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis.
Lijuan Yin, Qinlong Li, Stefan Mrdenovic, Gina Chia-Yi Chu, Boyang Jason Wu, Hong Bu, Peng Duan, Jayoung Kim, Sungyong You, Michael S. Lewis, Gangning Liang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung   +13 more
doaj   +3 more sources

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

mBio, 2022
Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis.
Yingxue Li, Wei Xu, Yutian Ren, Hung-Chi Cheung, Panpan Huang, Guneet Kaur, Chih-Jung Kuo, Sean P. McDonough, Susan L. Fubini, Stephen M. Lipkin, Xin Deng, Yung-Fu Chang, Linfeng Huang   +12 more
doaj   +2 more sources

Naxos Disease and Related Cardio-Cutaneous Syndromes [PDF]

JACC: Advances
Naxos disease is a rare autosomal recessive condition combining arrhythmogenic right ventricular cardiomyopathy, woolly hair, and palmoplantar keratoderma. The first identified causative variant was in the gene encoding the desmosomal protein plakoglobin.
Alexandros Protonotarios, MD, Angeliki Asimaki, Ph.D, Cristina Basso, MD, Zafeirenia Xylouri, MD, Emanuele Monda, MD, Ioannis Protonotarios, MD, Giulia Crisci, MD, Dominic JR. Abrahms, MMBS, MD, MBA, Aris Anastasakis, MD, Loizos Antoniades, MD, Athanasios Bakalakos, MD, Andreina Carbone, MD, Aman S. Coonar, MD, Juan Ramon Gimeno, MD, George Lazaros, MD, Stamatis Lerakis, MD, Luisa Mestroni, MD, George Papadopoulos, MD, Leandro Pecchia, MD, Francesca Romana Prandi, MD, Petros Syrris, MD, Julia Cadrin-Turigny, MD, Anargyros Vasilakis, MSc, Jeffrey E. Saffitz, MD, PhD, Stamatios Gaetano Thiene, MD, Perry M. Elliott, MD, Juan Pablo Kaski, MD, William J. McKenna, MD, Eduardo Bossone, MD, Giuseppe Limongelli, MD, Adalena Tsatsopoulou, MD   +30 more
doaj   +2 more sources