Results 211 to 220 of about 9,804 (231)

Localizing the adhesive and signaling functions of plakoglobin

Developmental Genetics, 1997
Plakoglobin (PKG) is a major component of cell-cell adhesive junctions. It is also closely related to the Drosophila segment polarity gene product armadillo and can induce a WNT-like neural axis duplication (NAD) phenotype in Xenopus [Kamovsky and Klymkowsky, 1995.] To define the regions of PKG involved in cell adhesion and inductive signaling, we ...
A, Rubenstein, J, Merriam, M W, Klymkowsky   +2 more
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Roles of plakoglobin end domains in desmosome assembly

Journal of Cell Science, 1997
ABSTRACT Plakoglobin, a member of the armadillo family of proteins, is a component of intercellular adhesive junctions. The central domain of plakoglobin comprises a highly conserved series of armadillo repeats that facilitate its association with either desmosomal or classic cadherins, or with cytosolic proteins such as the tumor ...
H L, Palka, K J, Green
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Expression of desmoglein I and plakoglobin in skin carcinomas

Journal of Cutaneous Pathology, 2000
Reduction or absence of cell‐cell adhesion molecules has been reported in various carinomas and the abnormal expression of these molecules contributes to the invasive and metastatic behavior of malignant tumor cells. In epidermal keratinocytes, the main cell‐cell adhesion systems are adherens junctions and desmosomes.
H, Tada, M, Hatoko, A, Tanaka, M, Kuwahara, T, Muramatsu   +4 more
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Plakoglobin induces desmosome formation and epidermoid phenotype in N‐cadherin‐expressing squamous carcinoma cells deficient in plakoglobin and E‐cadherin

Cell Motility and the Cytoskeleton, 1998
Pg is a homologue of beta-catenin and Armadillo, the product of the Drosophila segment polarity gene and has been shown to have both adhesive and signaling functions. It interacts with both classic and desmosomal cadherins. Pg interaction with the desmosomal cadherins is essential for desmosome assembly.
H R, Parker, Z, Li, H, Sheinin, G, Lauzon, M, Pasdar   +4 more
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Plakoglobin is a mechanoresponsive regulator of naïve pluripotency

2022
AbstractBiomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs could provide insight into mechanisms underlying mammalian pre-implantation development. Here, we explore this by exerting microenvironmental control over mouse embryonic
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellerman, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder   +15 more
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Strict correlation between uPAR and plakoglobin expression in pemphigus vulgaris

Journal of Cutaneous Pathology, 2002
Background:  Recent studies have reported nuclear delocalization of plakoglobin in acantholytic pemphigus vulgaris cells. The objective of this study was to evaluate the role of plakoglobin in the pathogenesis of acantholysis in pemphigus vulgaris (PV) and its relation with the urokinase‐type plasminogen activator receptor (uPAR) expression.Materials ...
Lo Muzio L, Pannone G, Staibano S, Mignogna MD, Rubini C, Farronato G, FERRARI, Francesca, NOCINI, Pier Francesco, De Rosa G.   +8 more
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Genomic organization and amplification of the human plakoglobin gene (JUP)

Experimental Dermatology, 2000
Abstract: Plakoglobin is a globular protein common to the intracellular plaques of adhesive junctions, predominantly desmosomes and adherens junctions. Recently, a number of pathogenic mutations have been described in other components of desmosomes, specifically in plakophilin 1, desmoplakin and desmoglein 1.
Whittock, N V, Eady, R A J, McGrath, J A
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Plakoglobin and β-catenin: Protein interactions, regulation and biological roles

Journal of Cell Science, 2000
ABSTRACT β-Catenin can play different roles in the cell, including one as a structural protein at cell-cell adherens junctions and another as a transcriptional activator mediating Wnt signal transduction. Plakoglobin (γ-catenin), a close homolog of β-catenin, shares with β-catenin common protein partners and can fulfill some of the same ...
J, Zhurinsky, M, Shtutman, A, Ben-Ze'ev
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Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders

Journal of Cell Science, 2001
ABSTRACT Desmosomes are adhesive junctions that link intermediate filament networks to sites of strong intercellular adhesion. These junctions play an important role in providing strength to tissues that experience mechanical stress such as heart and epidermis.
E A, Bornslaeger, L M, Godsel, C M, Corcoran, J K, Park, M, Hatzfeld, A P, Kowalczyk, K J, Green   +6 more
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Desmosomal Cadherins and Their Interactions with Plakoglobin

1996
Publisher Summary The amino acid sequences of both desmocollins and desmogleins display significant similarity to the ectodomains of classical cadherins but differ from them and from each other in the sequence of their cytoplasmic region. This chapter highlights the structural features and expression patterns of these proteins and focuses on their ...
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