Beta-Catenin and Plakoglobin Expression during Zebrafish Tooth Development and Replacement. [PDF]
PLoS ONE, 2016 We analyzed the protein distribution of two cadherin-associated molecules, plakoglobin and β-catenin, during the different stages of tooth development and tooth replacement in zebrafish.
Barbara Verstraeten +2 more
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Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation. [PDF]
PLoS ONE, 2014 The downregulation of E-cadherin function has fundamental consequences with respect to cancer progression, and occurs as part of the epithelial-mesenchymal transition (EMT). In this study, we show that the expression of the Discosoma sp.
Masayuki Ozawa, Wakako Kobayashi
doaj +1 more source
Cheek-Pro-Heart: What Can the Buccal Mucosa Do for Arrhythmogenic Cardiomyopathy?
Biomedicines, 2023 Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease associated with ventricular arrhythmias and a high risk of sudden cardiac death (SCD). Although the disease was described over 40 years ago, its diagnosis is still difficult.
Carlos Bueno-Beti, Angeliki Asimaki
doaj +1 more source
Desmosomal Cadherin Binding Domains of Plakoglobin [PDF]
Journal of Biological Chemistry, 1996 Plakoglobin is a major component of both desmosomes and adherens junctions. At these sites it binds to the cytoplasmic domains of cadherin cell-cell adhesion proteins and regulates their adhesive and cytoskeletal binding functions. Plakoglobin also forms distinct cytosolic protein complexes that function in pathways of tumor suppression and cell fate ...
L L, Witcher +6 more
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mBio, 2022 Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis.
Yingxue Li +12 more
doaj +1 more source
Plakoglobin expression in fibroblasts and its role in idiopathic pulmonary fibrosis [PDF]
, 2015 Stephanie Matthes +3 more
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Plakoglobin Deficiency Protects Keratinocytes from Apoptosis [PDF]
Journal of Investigative Dermatology, 2007 The armadillo family protein plakoglobin (Pg) is a well-characterized component of anchoring junctions, where it functions to mediate cell-cell adhesion and maintain epithelial tissue integrity. Although its closest homolog beta-catenin acts in the Wnt signaling pathway to dictate cell fate and promote proliferation and survival, the role of Pg in ...
Dusek, Rachel L. +9 more
openaire +2 more sources
Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells. [PDF]
PLoS ONE, 2014 Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year survival rate of
Petter Angell Olsen +6 more
doaj +1 more source
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. [PDF]
PLoS ONE, 2008 Presenilin1 (PS1) is a component of the gamma-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated.
Imma Raurell +6 more
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