Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets
Molecular Oncology, 2021 Both oncogenic and tumor suppressor functions have been described for junction plakoglobin (JUP), also known as γ‐catenin. To clarify the role of JUP in prostate cancer, JUP protein expression was immunohistochemically detected in a tissue microarray ...
Tanja Spethmann +11 more
doaj +2 more sources
Cancer Communications, 2021 Background Increased hypoxia‐inducible factor 2α (HIF2α) activation is a common event in clear cell renal cell carcinoma (ccRCC) progression. However, the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated. We conducted this study
Ke Chen +15 more
doaj +2 more sources
Cardiomyocyte adhesion and hyperadhesion differentially require ERK1/2 and plakoglobin
JCI Insight, 2020 Arrhythmogenic cardiomyopathy (AC) is a heart disease often caused by mutations in genes coding for desmosomal proteins, including desmoglein-2 (DSG2), plakoglobin (PG), and desmoplakin (DP).
Maria Shoykhet +7 more
doaj +2 more sources
PLoS ONE, 2012 To date, no plaque-derived blood biomarker is available to allow diagnosis, prognosis or monitoring of atherosclerotic vascular diseases. In this study, specimens of thrombendarterectomy material from carotid and iliac arteries were incubated in protein ...
Seraina Cooksley-Decasper +21 more
doaj +3 more sources
Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin
Frontiers in Immunology, 2019 Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
Dyah A. M. Oktarina +5 more
doaj +2 more sources
Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53. [PDF]
PLoS ONE, 2016 Aberrant expression of cadherins and catenins plays pivotal roles in ovarian cancer development and progression. Plakoglobin (PG, γ-catenin) is a paralog of β-catenin with dual adhesive and signaling functions.
Mahsa Alaee +2 more
doaj +2 more sources
Plakoglobin‐dependent disruption of the desmosomal plaque in pemphigus vulgaris [PDF]
Experimental Dermatology, 2007 Abstract: We recently reported that the pathogenesis of pemphigus vulgaris (PV), an autoimmune blistering skin disorder, is driven by the accumulation of c‐Myc secondary to abrogation of plakoglobin (PG)‐mediated transcriptional c‐Myc suppression.
Alain de Bruin +6 more
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Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo [PDF]
The Journal of Cell Biology, 2000 Plakoglobin regulates cell adhesion by providing a modulatable connection between both classical and desmosomal cadherins and their respective cytoskeletal linker proteins. Both plakoglobin and the related protein β-catenin are posttranscriptionally upregulated in response to Wnt-1 in cultured cells.
Emmanuelle Charpentier +3 more
openalex +5 more sources
Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma [PDF]
Disease Markers, 2021 Uterine carcinosarcoma (UCS) is a highly invasive malignant tumor that originated from the uterine epithelium. Many studies suggested that the abnormal changes of alternative splicing (AS) of pre-mRNA are related to the occurrence and metastasis of the ...
Hongjun Guo +12 more
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Genomic organization and amplification of the human plakoglobin gene (JUP) [PDF]
Experimental Dermatology, 2000 Abstract: Plakoglobin is a globular protein common to the intracellular plaques of adhesive junctions, predominantly desmosomes and adherens junctions. Recently, a number of pathogenic mutations have been described in other components of desmosomes, specifically in plakophilin 1, desmoplakin and desmoglein 1.
Neil V. Whittock +2 more
openalex +5 more sources