Results 41 to 50 of about 9,804 (231)

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core   +2 more sources

SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells

BMC Cell Biology, 2011
Background SOX4 is a developmental transcription factor that is required for differentiation and proliferation in multiple tissues. SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is still not well ...
Lai Yu-Heng, Cheng Jessica, Cheng Dongmei, Feasel Mattie E, Beste Kyle D, Peng Junmin, Nusrat Asma, Moreno Carlos S   +7 more
doaj   +1 more source

KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway

Breast Cancer Research, 2022
Background Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis.
Lijuan Yin, Qinlong Li, Stefan Mrdenovic, Gina Chia-Yi Chu, Boyang Jason Wu, Hong Bu, Peng Duan, Jayoung Kim, Sungyong You, Michael S. Lewis, Gangning Liang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung   +13 more
doaj   +1 more source

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. [PDF]

, 2016
Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood.
Johnson, Keith R., Kowalczyk, Andrew P., Lewis, Joshua D., Mahoney, My G., Overmiller, Andrew M., Roberts, Brett J., Svoboda, Robert A., Wahl, James K.   +7 more
core   +2 more sources

Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy. [PDF]

, 2019
Phospholamban (PLN) p.Arg14del cardiomyopathy is characterized by a distinct arrhythmogenic biventricular phenotype that can be predominantly left ventricular, right ventricular, or both.
Asimaki, A, de Boer, RA, Hoorntje, ET, Jongbloed, JDH, Lazzarini, E, Saffitz, JE, Suurmeijer, AJH, Te Rijdt, WP, van den Berg, MP, van der Zwaag, PA, van Tintelen, JP   +10 more
core   +6 more sources

Junction Plakoglobin - A Dual-Role Player in Cancer Biology. [PDF]

Int J Surg
Junction plakoglobin (JUP) is a critical cell adhesion molecule implicated in mediating cell-cell adhesion. Cancer, characterized by the loss of normal cellular regulation, results in unchecked proliferation and the breakdown of cell-cell junctions, facilitating malignant cell invasion into surrounding tissues.
Ding W, Sun J, Song S, Cui Y, Chen F, Yuan Q, Shang W.   +6 more
europepmc   +3 more sources

Lack of Plakoglobin in Epidermis Leads to Keratoderma [PDF]

Journal of Biological Chemistry, 2012
Loss-of-function mutation of Jup has been associated with Naxos disease, which is characterized by arrhythmogenic cardiomyopathy and the cutaneous disorder palmoplantar keratoderma. Previously, we have shown that genetic ablation of Jup in cardiomyocytes in mice leads to arrhythmogenic cardiomyopathy similar to Naxos disease in humans.
Deqiang, Li, Wenjun, Zhang, Ying, Liu, Laura S, Haneline, Weinian, Shou   +4 more
openaire   +2 more sources

The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels. [PDF]

PLoS ONE, 2013
The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from
Ryo Koyama-Nasu, Rina Takahashi, Satoshi Yanagida, Yukiko Nasu-Nishimura, Masaaki Oyama, Hiroko Kozuka-Hata, Ryo Haruta, Emi Manabe, Akemi Hoshino-Okubo, Hiroko Omi, Nozomu Yanaihara, Aikou Okamoto, Tadao Tanaka, Tetsu Akiyama   +13 more
doaj   +1 more source

A global perspective of arrhythmogenic right ventricular cardiomyopathy. [PDF]

, 2012
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive inherited heart disease characterized by ventricular arrhythmias and sudden cardiac death especially in the young. ARVC has been traditionally associated with the Mediterranean basin,
Alhashemi, M, Elmaghawry, M, Yacoub, MH, Zorzi, A   +3 more
core   +1 more source

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]

, 2012
The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +2 more sources