Results 41 to 50 of about 5,949 (220)
Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation. [PDF]
PLoS ONE, 2014 The downregulation of E-cadherin function has fundamental consequences with respect to cancer progression, and occurs as part of the epithelial-mesenchymal transition (EMT). In this study, we show that the expression of the Discosoma sp.
Masayuki Ozawa, Wakako Kobayashi
doaj +1 more source
The canonical way to make a heart: β-catenin and plakoglobin in heart development and remodeling [PDF]
Experimental biology and medicine, 2017 О. O. Piven, Cecilia Lanny Winata
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Desmosomal Cadherin Binding Domains of Plakoglobin [PDF]
Journal of Biological Chemistry, 1996 Plakoglobin is a major component of both desmosomes and adherens junctions. At these sites it binds to the cytoplasmic domains of cadherin cell-cell adhesion proteins and regulates their adhesive and cytoskeletal binding functions. Plakoglobin also forms distinct cytosolic protein complexes that function in pathways of tumor suppression and cell fate ...
Sailaja Puttagunta +6 more
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Lack of Plakoglobin in Epidermis Leads to Keratoderma [PDF]
Journal of Biological Chemistry, 2012 Loss-of-function mutation of Jup has been associated with Naxos disease, which is characterized by arrhythmogenic cardiomyopathy and the cutaneous disorder palmoplantar keratoderma. Previously, we have shown that genetic ablation of Jup in cardiomyocytes in mice leads to arrhythmogenic cardiomyopathy similar to Naxos disease in humans.
Weinian Shou +4 more
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Molecular cloning of a functional promoter of the human plakoglobin gene [PDF]
European Journal of Endocrinology, 2001 OBJECTIVE: Plakoglobin (Pg) is the only cytoplasmic protein component common to both junctional complexes mediating cell-cell adhesion, adherens junctions and desmosomes. In these complexes Pg appears to act as a linker protein anchoring transmembrane proteins of the cadherin superfamily to the actin cytoskeleton and intermediate filament system ...
E. Pötter +3 more
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Plakoglobin-dependent regulation of keratinocyte APOPTOSIS by Rnd3 [PDF]
Journal of Cell Science, 2012 The human epidermis is a self-renewing, stratified epithelial tissue that provides the protective function of the skin. The principal cell type within the epidermis is the keratinocyte and normal function of the epidermis requires that keratinocyte proliferation, differentiation and cell death be carefully controlled.
John K. Heath +3 more
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Cell-cell contact preserves cell viability via plakoglobin. [PDF]
PLoS ONE, 2011 Control over cell viability is a fundamental property underlying numerous physiological processes. Cell spreading on a substrate was previously demonstrated to be a major factor in determining the viability of individual cells. In multicellular organisms,
Qi Wei +2 more
doaj +1 more source
bioRxiv, 2022 The scaffold protein 14-3-3ζ is an established regulator of adipogenesis and postnatal adiposity. We and others have demonstrated that the 14-3-3ζ interactome to be diverse and dynamic, and it can be examined to identify novel regulators of physiological
F. Abou Azar +7 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2022 Arrhythmogenic cardiomyopathy is a heritable heart disease associated with desmosomal mutations, especially premature termination codon (PTC) variants. It is known that PTC triggers the nonsense-mediated decay (NMD) mechanism.
M. Vallverdú-Prats +2 more
semanticscholar +1 more source
Plakoglobin Deficiency Protects Keratinocytes from Apoptosis [PDF]
Journal of Investigative Dermatology, 2007 The armadillo family protein plakoglobin (Pg) is a well-characterized component of anchoring junctions, where it functions to mediate cell-cell adhesion and maintain epithelial tissue integrity. Although its closest homolog beta-catenin acts in the Wnt signaling pathway to dictate cell fate and promote proliferation and survival, the role of Pg in ...
Rachel L. Dusek +9 more
openaire +3 more sources