Results 51 to 60 of about 9,804 (231)

Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability.

Journal of Biological Chemistry, 1994
Desmosomes are adhesive intercellular junctions that act as cell surface attachment sites for intermediate filaments. The desmosomal glycoproteins, desmogleins and desmocollins, are members of the cadherin family of adhesion molecules. In addition, desmoglein has been shown to coimmunoprecipitate with the junctional protein plakoglobin. To characterize
A P, Kowalczyk, H L, Palka, H H, Luu, L A, Nilles, J E, Anderson, M J, Wheelock, K J, Green   +6 more
openaire   +2 more sources

Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens. [PDF]

, 2015
BackgroundTo determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.MethodsTen CLL specimens and five normal peripheral blood CD19+ B ...
A Ameur, A Choudhury, A Hidalgo, A Rosenwald, AS Kamiguti, C Haslinger, C Soo, C Trapnell, C Trapnell, CJ David, DC Gilby, E Moon, E Moravcikova, F Colotta, F Talab, FC Kelleher, Gwen Jordaan, H Dohner, H Jiang, J Eswaran, J Vilpo, JC Marioni, JJ Dongen van, JP Venables, K Inada, K Zen, L Chen, L Wang, L Yang, LQ Zhang, M Crespo, M Rehli, M Shinohara, M Sultan, Matteo Pelegrini, ML Hermiston, MW Pfaffl, N Chiorazzi, NA Twine, O Bermudez, P Guglielmi, P Kapranov, PG Ferreira, Phillipp Nham, Q Huang, RA Higgins, RI Fernando, RK Gandhirajan, RN Damle, Ryan T. Phan, S Anders, S Courtois, S Decker, S Falt, S Ibrahim, S Liu, S Ma, S Ren, S Shen, Sanjai Sharma, SM Russell, SP Shah, SR Gunn, T Ormsby, TJ Hamblin, U Klein, V Quesada, Wei Liao, XS Puente, Y Pawitan, Y Pekarsky, Y Yu, Z Wang   +72 more
core   +1 more source

Syntenin-1 is a promoter and prognostic marker of head and neck squamous cell carcinoma invasion and metastasis. [PDF]

, 2016
Metastasis represents a key factor associated with poor prognosis of head and neck squamous cell carcinoma (HNSC). However, the underlying molecular mechanisms remain largely unknown. In this study, our liquid chromatography with tandem mass spectrometry
Cheng, Siliangyu, Cui, Li, Hu, Shen, Liu, Xiaojun, Messadi, Diana, Yang, Yan   +5 more
core   +1 more source

Axin Directly Interacts with Plakoglobin and Regulates Its Stability [PDF]

Journal of Biological Chemistry, 1999
Plakoglobin is homologous to beta-catenin. Axin, a Wnt signal negative regulator, enhances glycogen synthase kinase (GSK)-3beta-dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin. Therefore, we examined the effect of Axin on plakoglobin stability. Axin formed a complex with plakoglobin in COS cells and SW480 cells.
S, Kodama, S, Ikeda, T, Asahara, M, Kishida, A, Kikuchi   +4 more
openaire   +2 more sources

Arrhythmogenic right ventricular cardiomyopathy in patients with biallelic JUP-associated skin fragility

Scientific Reports, 2020
Arrhythmogenic right ventricular cardiomyopathy (ARVC), with skin manifestations, has been associated with mutations in JUP encoding plakoglobin. Genotype–phenotype correlations regarding the penetrance of cardiac involvement, and age of onset have not ...
Hassan Vahidnezhad, Leila Youssefian, Masoomeh Faghankhani, Nikoo Mozafari, Amir Hossein Saeidian, Fatemeh Niaziorimi, Fahimeh Abdollahimajd, Soheila Sotoudeh, Fateme Rajabi, Liaosadat Mirsafaei, Zahra Alizadeh Sani, Lu Liu, Alyson Guy, Sirous Zeinali, Ariana Kariminejad, Reginald T. Ho, John A. McGrath, Jouni Uitto   +17 more
doaj   +1 more source

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin [PDF]

, 2012
Canonical Wnt signaling regulates the transcription of T-cell factor (TCF)-responsive genes through the stabilization and nuclear translocation of the transcriptional co-activator, β-catenin.
A Gandillet, A Tonks, AL Brown, AP Kowalczyk, BO Williams, BR Henderson, C Muller-Tidow, CC Chen, CH Jamieson, D Lu, E Krieghoff, E Serinsoz, EJ Chung, EK Siapati, F Fagotto, FJ Staal, FT Kolligs, G Jeannet, G Solanas, H Aberle, H Clevers, I Simcha, J Xu, J Yeung, J Zhurinsky, J Zhurinsky, JR Miller, L Ysebaert, M Cobas, M Pasdar, M Simon, ME Conacci-Sorrell, N Zhang, NI Khan, O Maeda, P Kirstetter, PJ Morin, PS Hole, R Majeti, RS Bradley, S Papagerakis, SG Hwang, T Kajiguchi, T Kajiguchi, T Reya, TC Luis, TL Biechele, U Koch, X Zheng, Y Fukunaga, Y Wang, YM Kim   +51 more
core   +2 more sources

Hepatitis B virus X protein and hepatitis C virus core protein cooperate to repress E-cadherin expression via DNA methylation

Heliyon, 2022
Dual infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) is closely associated with an increased risk of hepatocellular carcinoma; however, the underlying mechanism is poorly understood. In the present study, we found that HBV X protein (HBx)
Hyunyoung Yoon, Kyung Lib Jang
doaj   +1 more source

Micropapillary structure: A natural tumor collective invasion model with enhanced stem-like properties. [PDF]

Cancer Sci
By analyzing the cancer stem‐like phenotype, multiomics features, and molecular mechanisms of cell cluster formation and collective invasion of micropapillary carcinoma, and integrating the vascular and immune microenvironment of micropapillary carcinoma, it is suggested that micropapillary carcinoma has the potential to become a solid tumor model for ...
Li S, Gao S, Qin L, Ding C, Qu J, Cui Y, Qiang L, Yin S, Zheng X, Meng H.   +9 more
europepmc   +2 more sources

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) in clinical practice [PDF]

, 2017
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited myocardial disease characterized by fibro-fatty replacement of the right ventricular myocardium, and associated with paroxysmal ventricular arrhythmias and sudden cardiac ...
Antoniades, Aquaro, Avella, Bai, Bao, Battipaglia, Beffagna, Bhonsale, Bhonsale, Breithardt, Broch, Burghouwt, Calkins, Camm, Carvajal-Huerta, Chung, Corrado, D'Ascenzi, Dawson, Dechering, Erkapic, Ermakov, Ermakov, Femia, Fontaine, Gerull, Hamid, Hengel, Hoffmayer, Iriyama, Iyer, James, Jiang, Kataoka, Khaji, Kimura, Kirubakaran, Klauke, Leren, Lewis, Li, Liao, Lin, Lopez-Moreno, Mano, Marcus, Maron, Maron, Mayosi, McKenna, McKoy, Merner, Mussigbrodt, Mussigbrodt, Ohno, Opbergen, Peters, Peters, Peters, Philips, Pilichou, Platonov, Protonotarios, Protonotarios, Quarta, Rampazzo, Riele, Riele, Romero, Romero, Ruwald, Saffitz, Santangeli, Saprungruang, Schinkel, Sen-Chowdhry, Sen-Chowdhry, Sen-Chowdhry, Severini, Silvano, Souissi, Steckman, Sultan, Suzuki, Syrris, Taylor, Te Riele, Tiso, Tse, Tse, Tse, Tse, Vite, Wang, Ward, Wei, Weiner, Wichter, Wlodarska, Wu, Xu, Zhurinsky, Zwaag   +102 more
core   +2 more sources

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]

, 2016
Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona, Ceccarelli, Simona, Clerico, Anna, Dominici, Carlo, Mannarino, Olga, Marampon, Francesco, Marchese, Cinzia, Mcdowell, Heather P, Megiorni, Francesca, Pizer, Barry, Pizzuti, Antonio, Shukla, Rajeev   +11 more
core   +1 more source