Results 51 to 60 of about 5,949 (220)

Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells. [PDF]

PLoS ONE, 2014
Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year survival rate of
Petter Angell Olsen, Nina Therese Solberg, Kaja Lund, Tore Vehus, Monika Gelazauskaite, Steven Ray Wilson, Stefan Krauss   +6 more
doaj   +1 more source

Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. [PDF]

PLoS ONE, 2008
Presenilin1 (PS1) is a component of the gamma-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated.
Imma Raurell, Montserrat Codina, David Casagolda, Beatriz Del Valle, Josep Baulida, Antonio García de Herreros, Mireia Duñach   +6 more
doaj   +1 more source

Axin Directly Interacts with Plakoglobin and Regulates Its Stability [PDF]

Journal of Biological Chemistry, 1999
Plakoglobin is homologous to beta-catenin. Axin, a Wnt signal negative regulator, enhances glycogen synthase kinase (GSK)-3beta-dependent phosphorylation of beta-catenin and stimulates the degradation of beta-catenin. Therefore, we examined the effect of Axin on plakoglobin stability. Axin formed a complex with plakoglobin in COS cells and SW480 cells.
Toshimasa Asahara, Akira Kikuchi, Shinya Kodama, Michiko Kishida, Satoshi Ikeda   +4 more
openaire   +3 more sources

Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia

Scientific Reports, 2023
Despite evidence demonstrating persistent lung function deficits in preterm-born children, especially in those who had bronchopulmonary dysplasia (BPD) in infancy, the underlying biological mechanisms explaining these lung function deficits remain poorly
Christopher W. Course, Philip A. Lewis, Sarah J. Kotecha, Michael Cousins, Kylie Hart, W. John Watkins, Kate J. Heesom, Sailesh Kotecha   +7 more
doaj   +1 more source

Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability.

Journal of Biological Chemistry, 1994
Desmosomes are adhesive intercellular junctions that act as cell surface attachment sites for intermediate filaments. The desmosomal glycoproteins, desmogleins and desmocollins, are members of the cadherin family of adhesion molecules. In addition, desmoglein has been shown to coimmunoprecipitate with the junctional protein plakoglobin. To characterize
Helena L. Palka, Margaret J. Wheelock, Kathleen J. Green, Laura A. Nilles, Andrew P. Kowalczyk, John E. Anderson, Hue H. Luu   +6 more
openaire   +2 more sources

A comparative evaluation of β-catenin and plakoglobin signaling activity [PDF]

Oncogene, 2000
Vertebrates have two Armadillo-like proteins, beta-catenin and plakoglobin. Mutant forms of beta-catenin with oncogenic activity are found in many human tumors, but plakoglobin mutations are not commonly found. In fact, plakoglobin has been proposed to suppress tumorigenesis.
Bart O. Williams, Harold E. Varmus, Harold E. Varmus, Michael W. Klymkowsky, Grant D. Barish   +4 more
openaire   +2 more sources

DEAD-Box Helicase 6 Blockade in Brain-Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity. [PDF]

MedComm (2020)
We identified four proteins (DSP, JUP, HRNR, and DDX6) that bind to amyloid‐beta (Aβ) oligomers derived from the brains of Alzheimer's disease (AD) patients. Among these four proteins, only the blockade of DEAD‐box helicase 6 (DDX6) in AD brain‐derived Aβ oligomers attenuated their neurotoxicity.
Wang X, Dai L, Wu N, Wu D, Wang X, Meng X, Zhang Q, Lu J, Yan X, Zhang J, Chen B.   +10 more
europepmc   +2 more sources

Immunofluorescent Localization of Plakoglobin Is Altered in Endomyocardial Biopsy Samples from Dogs with Clinically Relevant Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Veterinary Sciences, 2021
Diagnosing the early stages of canine Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is complicated by day-to-day arrhythmia variability, and absence of reliable, transthoracic echocardiographic features.
E. M. Oxford, R. Pariaut, M. Tursi, P. Fox, R. Santilli   +4 more
semanticscholar   +1 more source

Plakoglobin Is Required for Effective Intermediate Filament Anchorage to Desmosomes [PDF]

Journal of Investigative Dermatology, 2008
Desmosomes are adhesive junctions that provide mechanical coupling between cells. Plakoglobin (PG) is a major component of the intracellular plaque that serves to connect transmembrane elements to the cytoskeleton. We have used electron tomography and immunolabeling to investigate the consequences of PG knockout on the molecular architecture of the ...
Eliane J. Müller, David L. Stokes, Christopher Petzold, David D. Sabatini, Pamela Cowin, Devrim Acehan, Iwona Gumper   +6 more
openaire   +3 more sources

The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels. [PDF]

PLoS ONE, 2013
The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from
Ryo Koyama-Nasu, Rina Takahashi, Satoshi Yanagida, Yukiko Nasu-Nishimura, Masaaki Oyama, Hiroko Kozuka-Hata, Ryo Haruta, Emi Manabe, Akemi Hoshino-Okubo, Hiroko Omi, Nozomu Yanaihara, Aikou Okamoto, Tadao Tanaka, Tetsu Akiyama   +13 more
doaj   +1 more source