Results 61 to 70 of about 5,949 (220)

Plakoglobin and HMGB1 mediate intestinal epithelial cell apoptosis induced by Clostridioides difficile TcdB

bioRxiv, 2021
Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis.
Yingxue Li, Wei Xu, Yutian Ren, Hung-Chi Cheung, Panpan Huang, Guneet Kaur, C. Kuo, S. McDonough, S. Fubini, S. Lipkin, X. Deng, Yungfu Chang, Linfeng Huang   +12 more
semanticscholar   +1 more source

Arrhythmogenic right ventricular cardiomyopathy in patients with biallelic JUP-associated skin fragility

Scientific Reports, 2020
Arrhythmogenic right ventricular cardiomyopathy (ARVC), with skin manifestations, has been associated with mutations in JUP encoding plakoglobin. Genotype–phenotype correlations regarding the penetrance of cardiac involvement, and age of onset have not ...
Hassan Vahidnezhad, Leila Youssefian, Masoomeh Faghankhani, Nikoo Mozafari, Amir Hossein Saeidian, Fatemeh Niaziorimi, Fahimeh Abdollahimajd, Soheila Sotoudeh, Fateme Rajabi, Liaosadat Mirsafaei, Zahra Alizadeh Sani, Lu Liu, Alyson Guy, Sirous Zeinali, Ariana Kariminejad, Reginald T. Ho, John A. McGrath, Jouni Uitto   +17 more
doaj   +1 more source

Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin [PDF]

Oncogenesis, 2012
Nucleophosmin (NPM) is a nucleolar phosphoprotein that is involved in many cellular processes and has both oncogenic and growth suppressing activities. NPM is localized primarily in nucleoli but shuttles between the nucleus and the cytoplasm, and sustained cytoplasmic distribution contributes to its tumor promoting activities.
CY Kuo, M Bishay, Le Lam, Zackie Aktary, N Srivastava, John R. Mackey, Manijeh Pasdar, M Heacock, C Werkman   +8 more
openaire   +3 more sources

Expression of desmosomal proteins and their implications during enamel organ morphogenesis

Indian Journal of Dental Sciences, 2018
Background/Objective: The present article is between the fewest that describe the expression of desmosomal proteins in human tooth organ and to implicate desmosome and its components in tooth morphogenesis.
Hadi BILAL
doaj   +1 more source

Long‐term remission of Hailey–Hailey disease by Er:YAG ablative laser therapy

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 5, Page 1038-1045, May 2025.
Upper left panel: Hailey–Hailey lesion at baseline, directly after, 6 weeks and 3 years after a single Er:YAG laser ablation. Long‐term remission was noted in 75/77 Hailey–Hailey plaques after a median follow‐up of 38 months. Upper right panel: Median quality of life scores at baseline, 6 weeks and 3 years after laser ablation with a significant ...
Marie‐Eline P. H. Debeuf, Kèvin Knoops, Carmen López‐Iglesias, Eline Lookermans, Patty J. Nelemans, Myrurgia Abdul Hamid, Michel van Geel, Antoni H. Gostynski, Peter M. Steijlen, Marieke C. Bolling, Valerie L. R. M. Verstraeten   +10 more
wiley   +1 more source

Cardiac sympathetic neurons are additional cells affected in genetically determined arrhythmogenic cardiomyopathy

The Journal of Physiology, Volume 603, Issue 7, Page 1959-1982, 31 March 2025.
Abstract figure legend Cardiac sympathetic neurons express desmoglein‐2 (DSG2) and harbour mutations in DSG2‐linked arrhythmogenic cardiomyopathy. DSG2 mutations affect sympathetic neuron biology (i.e. reduced axonal sprouting, irregular distribution of varicosities) and result in aberrant cardiac innervation.
Induja Perumal Vanaja, Arianna Scalco, Marco Ronfini, Anna Di Bona, Camilla Olianti, Stefania Rizzo, Stephen P. Chelko, Domenico Corrado, Leonardo Sacconi, Cristina Basso, Marco Mongillo, Tania Zaglia   +11 more
wiley   +1 more source

Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. IMPLICATIONS FOR THE REGULATION OF β-CATENIN/Tcf-4-DEPENDENT TRANSCRIPTION. [PDF]

Journal of Biological Chemistry, 2006
Alzheimer disease-linked Presenilin-1 (PS1) is a negative modulator of beta-catenin/Tcf-4 activity. However, the mechanism underlying this effect is not well understood. We show here that the effects of PS1 on the activity of this complex in epithelial cells are independent of its gamma-secretase activity and its interaction with beta-catenin.
Clara Francí, Antonio García de Herreros, Imma Raurell, Mireia Duñach, Julio Castaño   +4 more
openaire   +5 more sources

Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma.

Oncology Letters, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, and it is associated with a 5-year survival rate of
E. Nweke, M. Ntwasa, M. Brand, J. Devar, Martin Smith, G. Candy   +5 more
semanticscholar   +1 more source

Understanding host's response to staphylococcal scalded skin syndrome

Acta Paediatrica, Volume 114, Issue 2, Page 241-247, February 2025.
Abstract Aim The aim of this review was to summarise the current knowledge on host‐related factors that contribute to the development and severity of staphylococcal scalded skin syndrome (SSSS) in children. Methods A comprehensive assessment and analysis of the existing literature on SSSS clinical features, pathogenesis and susceptibility factors ...
Glykeria Rouva, Eleni Vergadi, Konstantinos Krasagakis, Emmanouil Galanakis   +3 more
wiley   +1 more source

The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling. [PDF]

PLoS ONE, 2012
Plakoglobin (PG) is an armadillo protein that associates with both classic and desmosomal cadherins, but is primarily concentrated in mature desmosomes in epithelia.
Carrie A Franzen, Viktor Todorović, Bhushan V Desai, Salida Mirzoeva, Ximing J Yang, Kathleen J Green, Jill C Pelling   +6 more
doaj   +1 more source