Results 81 to 90 of about 9,804 (231)

A comparative evaluation of β-catenin and plakoglobin signaling activity [PDF]

Oncogene, 2000
Vertebrates have two Armadillo-like proteins, beta-catenin and plakoglobin. Mutant forms of beta-catenin with oncogenic activity are found in many human tumors, but plakoglobin mutations are not commonly found. In fact, plakoglobin has been proposed to suppress tumorigenesis.
B O, Williams, G D, Barish, M W, Klymkowsky, H E, Varmus   +3 more
openaire   +2 more sources

Striatins as plaque molecules of zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinoma-derived cells [PDF]

, 2014
Proteins of the striatin family (striatins 1–4; sizes ranging from 90 to 110 kDa on SDS-polyacrylamide gel electrophoresis) are highly homologous in their amino acid sequences but can differ in their cell-type-specific gene expression patterns and ...
Dörflinger, Yvette, Franke, Werner W., Frey, Norbert, Heid, Hans, Kuhn, Caecilia, Rickelt, Steffen, Rosin-Arbesfeld, Rina, Zimbelmann, Ralf   +7 more
core   +2 more sources

Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior

Advanced Healthcare Materials, Volume 14, Issue 30, November 25, 2025.
Fibrous structures are key elements of the native extracellular matrix and crucial for directing cell behavior. This review discusses how fiber properties such as composition, diameter, and alignment affect cell responses in 2D and 3D systems. Strategies for integrating fibrous cues into engineered tissues are highlighted, and future directions for ...
Zan Lamberger, Gregor Lang
wiley   +1 more source

Cardiomyocyte adhesion and hyperadhesion differentially require ERK1/2 and plakoglobin

JCI Insight, 2020
Arrhythmogenic cardiomyopathy (AC) is a heart disease often caused by mutations in genes coding for desmosomal proteins, including desmoglein-2 (DSG2), plakoglobin (PG), and desmoplakin (DP).
Maria Shoykhet, Sebastian Trenz, Ellen Kempf, Tatjana Williams, Brenda Gerull, Camilla Schinner, Sunil Yeruva, Jens Waschke   +7 more
doaj   +1 more source

Discovery of Digenic Mutation, KCNH2 c.1898A >C and JUP c.916dupA, in a Chinese Family with Long QT Syndrome via Whole-Exome Sequencing

Cardiovascular Innovations and Applications, 2020
Long QT syndrome (LQTS), which is caused by an ion channel–related gene mutation, is a malignant heart disease with a clinical course of a high incidence of ventricular fibrillation and sudden cardiac death in the young. Mutations in KCNH2 (which encodes
Yafei Zhai, Jinxin Miao, Ying Peng, Guangming Fang, Chuchu Wang, Yaohe Wang, Xiaoyan Zhao, Jianzeng Dong   +7 more
doaj   +1 more source

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

Advanced Therapeutics, Volume 8, Issue 11, November 2025.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn, Seonmin Choi, Minju Kim, Zachary Estlack, Daniel Brown, Jaehong Key, Young Joon Seo, Jungkyu Kim   +7 more
wiley   +1 more source

The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling. [PDF]

PLoS ONE, 2012
Plakoglobin (PG) is an armadillo protein that associates with both classic and desmosomal cadherins, but is primarily concentrated in mature desmosomes in epithelia.
Carrie A Franzen, Viktor Todorović, Bhushan V Desai, Salida Mirzoeva, Ximing J Yang, Kathleen J Green, Jill C Pelling   +6 more
doaj   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, Volume 8, Issue 10, October 2025.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. [PDF]

, 2018
OBJECTIVES: The purpose of this study was to assess the phenotype of Filamin C (FLNC) truncating variants in dilated cardiomyopathy (DCM) and understand the mechanism leading to an arrhythmogenic phenotype. BACKGROUND: Mutations in FLNC are known to lead
Abecasis, Asimaki, Asimaki, Asimaki, Begay, Brodehl, Campbell, Chelko, Daughenbaugh, Deo, Furst, Golbus, Gontier, Haas, Hershberger, Kley, Kley, Landrum, Lek, Liu, Marcus, Mestroni, Ortiz-Genga, Rowland, Spezzacatene, Valdes-Mas, van, Wang, Wu, Zhou   +29 more
core   +2 more sources

Gene Therapy Targeting Pkp2 Deficiency Attenuates Cardiac Fibrosis: Insights From Single‐Cell Transcriptomics in Pkp2‐Knockout Rats

MedComm, Volume 6, Issue 10, October 2025.
PKP2 acts as a master switch for the progression of fibrosis in heart failure. ABSTRACT Heart failure (HF), characterized by maladaptive cardiac fibrosis and progressive functional deterioration, remains a therapeutic challenge. In this study, we established a cardiac organoid HF model derived from human‐induced pluripotent stem cells (hiPSCs) and ...
Xinyue Ding, Hui Zhang, Xuan Zhao, Nengpin Yin, Shuo Han, Xiao Jin, Tingting Li, Lina Xing, Zhen Qi, Yanan Zhu, Xin Wang, Zongjun Liu   +11 more
wiley   +1 more source