Results 111 to 120 of about 1,593,802 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Formation of Nurses at Universidad de Antioquia: A Reality embodied in its Study Plans
Investigación y Educación en Enfermería, 2020 The article presents the trajectory of the study plans that have guided the formation of nursing professionals at Universidad de Antioquia in Medellín (Colombia). It presents the principal milestones or events that at a given moment determined significant ruptures in the formation processes and which show how this Faculty of Nursing, in its 70 years of
openaire +6 more sources
Recommandations du groupe de travail urfist [PDF]
Ce rapport présente les conclusions d\u27un groupe de travail présidé par Pierre Carbone, inspecteur général des bibliothèques, sur l\u27évolution du réseau des Unités régionales de formation à l\u27information scientifique et technique (URFIST) dans ...
Carbone, Pierre
core
O plan de la Ribera (1965) como ponto de convergência dos processos de regeneraçâo urbana na frente marítima. [PDF]
, 2018 Màster Oficial en Disseny Urbà: Art, Ciutat, Societat. Facultat de Belles Arts de la UB, curs: 2017-2018, Tutor:[por] O presente trabalho final de mestrado objetiva a apresentação de investigação sobre o conjunto de processos e projetos para a formação ...
Berri, André Luis
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
La educación de adultos en el marco universitario: los planes de formación de padres [PDF]
, 2004 [Resumen] El vertiginoso avance de la sociedad implica la necesidad de articular mecanismos que permitan una adaptación más adecuada de los ciudadanos a las nuevas exigencias sociales.
Díaz Rincón, Begoña +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Médiations & MédiatisationsEn France, les INSPÉ (Instituts nationaux supérieurs du professorat et de l’Éducation) forment les étudiants aux métiers du professorat, de l’éducation et de la formation.
Léa Degeuse, Alain Sénécail
doaj +1 more source