Results 121 to 130 of about 1,588,042 (310)

"C'est assez" : programme de détection et d'orientation des adultes concernés par la violence : origines et développements 2000-2004 [PDF]

, 2004
[Table des matières] Résumé. 1. La violence, un problème de santé publique ? 1.1. Quelques jalons historiques récents. 1.2. Définitions et typologie. 1.3. Données épidémiologiques suisses. 1.4. Conséquences sanitaires et sociales. 1.5.
Hofner, Marie-Claude, Viens Python, Nataly   +1 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Estructura del plan de crisis [PDF]

, 2003
Son muchos los factores que tenemos que tener en cuenta para prevenir una situación de crisis o para actuar cuando la situación ya ha estallado.
Sánchez Calero, María Luisa
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Bien communiquer sur sa thèse, suite.

EspacesTemps.net, 2005
Après une brève présentation sur lui-même, Edouard Paulino du Craft (Centre de recherche et d’appui pour la formation et ses technologies, qui travaille à l’ Epfl ) lance le débat : que signifie communiquer sur sa thèse ?
Philippe Heller
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A contribution to an understanding of landscape development through three-dimensional morphological analysis of a pedological cover (Paulinia, State of Sao Paulo, Brazil) = Contribution à l'analyse morphologique tridimensionnelle de la couverture pédologique à la reconstitution de l'évolution du modelé (Paulinia, Etat de Sao Paulo, Brésil) [PDF]

, 1995
L'organisation tridimensionnelle d'une couverture pédologique, comprenant l'étude des relations géométriques entre horizons, et particulièrement des relations de concordance ou de discordance, permet de reconstituer certaines étapes de l'évolution du ...
Boulet, René, Curmi, P., Pellerin, J., Pereira de Queiroz-Neto, J.   +3 more
core  

Models of Giant Planet formation with migration and disc evolution

, 2004
We present a new model of giant planet formation that extends the core-accretion model of Pollack etal (1996) to include migration, disc evolution and gap formation.
Alexander, Alibert, Bate, Beckwith, Bell, Bodenheimer, Boss, C. Mordasini, C. Winisdoerffer, Calvet, Chevalier, Field, Greenzweig, Haisch, Henderson, Hills, Ida, Ikoma, Korykansky, Lin, Lin, Lin, Lissauer, Lynden-Bell, Mac Low, Mayor, Menou, Nelson, Papaloizou, Perri, Podolak, Pollack, Revelle, Roulston, Saumon, Sekanina, Shakura, Sharp, Sibulkin, Svetsov, Takata, Tanaka, Tanaka, Tanaka, Thommes, Veras, W. Benz, Ward, Wetherill, Y. Alibert, Zahnle, Zahnle   +51 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source