Results 121 to 130 of about 141,844 (268)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The pathoanatomy of cancer: order in paradox. [PDF]

EBioMedicine
Höckel M.
europepmc   +1 more source

Memoire : formation des enseignants de FLE dans les ecoles secondaires de Mutare au Zimbabwe : analyse des besoins et plan de formation

, 2011
Ce mémoire est un des requis des études de Masters TFFL (Teaching French as a Foreign Language) à UCT (University of Cape Town) dont le but est de montrer l’acquisition des compétences par la mise en place d’une recherche-développement. Il porte sur la formation des enseignants de FLE (Français Langue Etrangère) dans notre pays, le Zimbabwe, et ...
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Synthesis of a Highly Fluorescent Quinoxalino[2,3-<i>b</i>]quinoxaline Polycyclic Derivative via Intramolecular Michael Addition to a Squaramide Ring. [PDF]

J Org Chem
Picci G, Milia J, Lippolis V, Ricci PC, Frontera A, Gomila RM, Ojah EO, De Silva Weerakonda Arachchige RD, Orton JB, Coles SJ, Busschaert N, Caltagirone C.   +11 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

In-depth 3D exploration of autosomal dominant polycystic kidney disease through light sheet fluorescence microscopy. [PDF]

Sci Rep
Delgado-Rodriguez P, Vitoria I, Ríos-Muñoz GR, Bardia L, Lamanna-Rama N, Nicolas-Saenz L, Sporring J, Soto-Montenegro ML, Aldabe R, Colombelli J, Muñoz-Barrutia A.   +10 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Footprint morphology sheds light on running strategies in non-avian theropods. [PDF]

Sci Rep
Díaz-Martínez I, Navarro-Lorbés P, Isasmendi E, Páramo A, Gascó-Lluna F, Torices A, Ruiz J, Viera LI, Sáez-Benito P, Farlow J, Leonardi G, Pereda-Suberbiola X, Citton P.   +12 more
europepmc   +1 more source