Results 301 to 310 of about 150,481 (338)
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Fidelity in planar cell polarity signalling
Nature, 2003The polarity of Drosophila wing hairs displays remarkable fidelity. Each of the approximately 30,000 wing epithelial cells constructs an actin-rich prehair that protrudes from its distal vertex and points distally. The distal location and orientation of the hairs is virtually error free, thus forming a nearly perfect parallel array.
Dali, Ma +4 more
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Planar cell polarity and cilia
Seminars in Cell & Developmental Biology, 2009In the last few years, evidence has come to light suggesting that planar cell polarity signaling in vertebrates may be controlled and modulated by primary cilia, subcellular organelles that emerge from the plasma membrane of most cell types. This characteristic distinguishes vertebrate planar cell polarity signaling from that in insects. We review here
Evelyne, Fischer, Marco, Pontoglio
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Insight into planar cell polarity
Experimental Cell Research, 2014Planar cell polarity or PCP refers to a uniform cellular organization within the plan, typically orthogonal to the apico-basal polarity axis. As such, PCP provides directional cues that control and coordinate the integration of cells in tissues to build a living organism. Although dysfunctions of this fundamental cellular process have been convincingly
Michael, Sebbagh, Jean-Paul, Borg
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Planar cell polarity and vertebrate organogenesis
Seminars in Cell & Developmental Biology, 2006In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell ...
Courtney, Karner +2 more
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Science, 2005
Epithelial cells of many organisms show planar cell polarity. In the Drosophila wing, hexagonally packed cells accumulate various planar cell polarity signaling components in localized areas (proximally or distally), and an actin-rich hair develops from the distal vertex and points distally.
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Epithelial cells of many organisms show planar cell polarity. In the Drosophila wing, hexagonally packed cells accumulate various planar cell polarity signaling components in localized areas (proximally or distally), and an actin-rich hair develops from the distal vertex and points distally.
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Cell division orientation and planar cell polarity pathways
Seminars in Cell & Developmental Biology, 2009The orientation of cell division has a crucial role in early embryo body plan specification, axis determination and cell fate diversity generation, as well as in the morphogenesis of tissues and organs. In many instances, cell division orientation is regulated by the planar cell polarity (PCP) pathways: the Wnt/Frizzled non-canonical pathway or the Fat/
Segalen, Marion, Bellaïche, Yohanns
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Planar cell polarity signaling in neural development
Current Opinion in Neurobiology, 2010Planar cell polarity (PCP), the organization of cell sheets in the tangential plane, is regulated by a set of 'core' PCP genes. Over the last few years, evidence has accumulated that PCP signaling is important for brain development and function. PCP signaling in the neuroepithelium and otic placode controls neural tube closure, the organization of ...
Fadel, Tissir, André M, Goffinet
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Planar Cell Polarity Goes Perpendicular
Science Signaling, 2014The planar cell polarity pathway influences the apicobasal distribution of a cell fate determinant.
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Wnt Regulation of Planar Cell Polarity (PCP)
2012Planar cell polarity (PCP), a process controlling coordinated, uniformly polarized cellular behaviors in a field of cells, has been identified to be critically required for many fundamental developmental processes. However, a global directional cue that establishes PCP in a three-dimensional tissue or organ with respect to the body axes remains elusive.
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Planar Cell Polarity in the Inner Ear
2012The inner ears of vertebrates represent one of the most striking examples of planar cell polarity (PCP). Populations of directionally sensitive mechanosensory hair cells develop actin-based stereociliary bundles that are uniformly oriented. Analysis of perturbations in bundle polarity in mice with mutations in Vangl2 formed the basis for the initial ...
Helen, May-Simera, Matthew W, Kelley
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