Results 171 to 180 of about 5,277,200 (190)
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Biochemical and Biophysical Research Communications, 2009
The planar cell polarity (PCP) pathway, a beta-catenin-independent branch of the Wnt signaling pathway, orients cells and their appendages with respect to the body axes. Diversin, the mammalian homolog of the Drosophila PCP protein Diego, acts as a molecular switch that blocks beta-catenin-dependent and promotes beta-catenin-independent Wnt signaling ...
Kassiani Skouloudaki +2 more
exaly +5 more sources
The planar cell polarity (PCP) pathway, a beta-catenin-independent branch of the Wnt signaling pathway, orients cells and their appendages with respect to the body axes. Diversin, the mammalian homolog of the Drosophila PCP protein Diego, acts as a molecular switch that blocks beta-catenin-dependent and promotes beta-catenin-independent Wnt signaling ...
Kassiani Skouloudaki +2 more
exaly +5 more sources
Wnt16 regulates chondrocyte differentiation through Wnt/ planar cell polarity (PCP) pathway
The FASEB Journal, 2018 Wnt signaling, a highly conserved signaling pathway, plays important roles in endochondral ossification which is a key process for skeletal development and bone repair. Wnt16, as one of the nineteen Wnt ligands, is reported to repress osteoclastogenesis, prevent cortical bone fragility fractures and to be upregulated in ...
Yelin Zeng, Wai Yueng, K. L. Mak, H Zhao
semanticscholar +2 more sources
Planar cell polarity (PCP) and Wnt signaling in renal disease
Drug Discovery Today: Disease Mechanisms, 2013Dysfunctional cilia cause kidney cysts. Most cilia are non-motile (primary) microtubular organelles expressed on epithelial cells that are thought to translate global positional cues into planar cell polarity (PCP), a pathway ascribed to non-canonical Wnt signaling.
A. Ganner, S. Lienkamp, G. Walz
semanticscholar +2 more sources
Developmental Biology, 2008 Frizzled (Fz)/PCP signaling regulates planar, vectorial orientation of cells or groups of cells within whole tissues. Although Fz/PCP signaling has been analyzed in several contexts, little is known about nuclear events acting downstream of Fz/PCP signaling in the R3/R4 cell fate decision in the Drosophila eye or in other contexts.
Marek Mlodzik +2 more
exaly +3 more sources
Cell Research, 2017 Planar cell polarity (PCP) is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior during embryonic development.
Wei Yang, Bo Gao, Xilin Liu
exaly +2 more sources
The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function.
EndocrinologyFat (FAT atypical cadherin) and Dchs (Dachsous cadherin-related protein) in adjacent Sertoli:Sertoli, Sertoli:spermatid, and spermatid:spermatid create an important intercellular bridge, whose adhesive function is in turn supported by Fjx1, a non ...
Tiao Bu +9 more
semanticscholar +1 more source
Neuroscience, 2022
The Planar cell polarity (PCP) pathway is known to mediate the function of the Wnt proteins in growth cone guidance. Here, we show that the PCP pathway may directly influence local protein synthesis within the growth cones.
Pau Marfull-Oromí +2 more
semanticscholar +1 more source
The Planar cell polarity (PCP) pathway is known to mediate the function of the Wnt proteins in growth cone guidance. Here, we show that the PCP pathway may directly influence local protein synthesis within the growth cones.
Pau Marfull-Oromí +2 more
semanticscholar +1 more source
Differentiation, 2017
The Wnt/planar cell polarity (PCP) pathway directs cell migration during vertebrate gastrulation and is essential for proper embryonic development. Paraxial protocadherin (PAPC, Gene Symbol pcdh8.2) is an important activator of Wnt/PCP signaling during Xenopus gastrulation, but how PAPC activity is controlled is incompletely understood.
Rahul, Kumar +4 more
openaire +2 more sources
The Wnt/planar cell polarity (PCP) pathway directs cell migration during vertebrate gastrulation and is essential for proper embryonic development. Paraxial protocadherin (PAPC, Gene Symbol pcdh8.2) is an important activator of Wnt/PCP signaling during Xenopus gastrulation, but how PAPC activity is controlled is incompletely understood.
Rahul, Kumar +4 more
openaire +2 more sources
Clinical Cancer Research, 2016
Abstract Ovarian cancer (OC), in particular high grade serous carcinoma (HGSC), has been shown to exhibit diverse molecular heterogeneity based on gene expression profiling by the Australian and the TCGA cohorts. This molecular heterogeneity has been demonstrated to be very robust and reproducible by a large-scale meta-analysis study ...
Mohammad Asad +5 more
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Abstract Ovarian cancer (OC), in particular high grade serous carcinoma (HGSC), has been shown to exhibit diverse molecular heterogeneity based on gene expression profiling by the Australian and the TCGA cohorts. This molecular heterogeneity has been demonstrated to be very robust and reproducible by a large-scale meta-analysis study ...
Mohammad Asad +5 more
openaire +1 more source
Epithelial polarization by the core planar cell polarity complex is exclusively non-autonomous
ScienceFor cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown whether asymmetric segregation of PCP complexes requires
L. Basta +3 more
semanticscholar +1 more source