Results 1 to 10 of about 10,466 (207)

Protein Core Fucosylation Regulates Planarian Head Regeneration via Neoblast Proliferation

Frontiers in Cell and Developmental Biology, 2021
Protein glycosylation is an important posttranslational modification that plays a crucial role in cellular function. However, its biological roles in tissue regeneration remain interesting and primarily ambiguous.
Wenjun Wang, Yuan Yu, Yuan Yu, Yuan Yu, Hongbo Liu, Hanxue Zheng, Liyuan Jia, Jing Zhang, Xue Wang, Yang Yang, Yang Yang, Yang Yang, Fulin Chen, Fulin Chen, Fulin Chen   +14 more
doaj   +2 more sources

Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

eLife, 2021
In order to regenerate tissues successfully, stem cells must detect injuries and restore missing cell types through largely unknown mechanisms. Planarian flatworms have an extensive stem cell population responsible for regenerating any organ after ...
Tisha E Bohr, Divya A Shiroor, Carolyn E Adler   +2 more
doaj   +2 more sources

A comparative analysis of planarian genomes reveals regulatory conservation in the face of rapid structural divergence

Nature Communications
The planarian Schmidtea mediterranea is being studied as a model species for regeneration, but the assembly of planarian genomes remains challenging.
Mario Ivanković, Jeremias N. Brand, Luca Pandolfini, Thomas Brown, Martin Pippel, Andrei Rozanski, Til Schubert, Markus A. Grohme, Sylke Winkler, Laura Robledillo, Meng Zhang, Azzurra Codino, Stefano Gustincich, Miquel Vila-Farré, Shu Zhang, Argyris Papantonis, André Marques, Jochen C. Rink   +17 more
doaj   +2 more sources

Genotoxicity Evaluation of Metformin in Freshwater Planarian Dugesia japonica by the Comet Assay and RAPD Analysis [PDF]

BioMed Research International, 2022
Objective To investigate the genotoxicity of metformin on planarian with different concentrations and exposure times. Methods The planarians were treated, respectively, with 10 mmol/L and 50 mmol/L metformin for 1, 3, and 5 days, and then, the comet ...
Dandan Yin, Zhenbiao Xu, Minmin Feng, Zelong Zhao, Dahu Chen, Linxia Song   +5 more
semanticscholar   +2 more sources

Systemic identification and characterization of the conserved core NuRD complex in planarian [PDF]

Frontiers in Aging
The nucleosome remodeling and deacetylase (NuRD) complex, well known for its ATP-dependent chromatin remodeling and histone deacetylation activities combined in one multi-subunit complex, plays an evolutionarily conserved role in chromatin structures and
Lei Huang, Hao Wang, Shuang Wu, Jiangnan Chai, Xiaopeng Zou, Hongfei Liu, Zhengwei Guo, Yanming Wang, Yunchao Kan, Yunchao Kan   +9 more
doaj   +2 more sources

Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians [PDF]

Biomolecules
Ibrutinib (IB), a Bruton’s tyrosine kinase (BTK) inhibitor, is widely used against B-cell malignancies. However, its adverse effects on stem cell-dependent processes and tissue homeostasis remain incompletely understood.
Weiyun Guo, Baijie Jin, Nannan Li, Dandan Sun, Dezeng Liu, Zimei Dong, Guangwen Chen   +6 more
doaj   +2 more sources

3D reconstruction of neuronal allometry and neuromuscular projections in asexual planarians using expansion tiling light sheet microscopy. [PDF]

Elife
Lu J, Xu H, Wang D, Chen Y, Inoue T, Gao L, Lei K.   +6 more
europepmc   +4 more sources

Extracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the Planarian Schmidtea mediterranea [PDF]

Journal of Extracellular Biology
Extracellular vesicles (EVs) are secreted nanoparticles composed of a lipid bilayer that carry lipid, protein, and nucleic acid cargo between cells as a mode of intercellular communication.
Priscilla N. Avalos Najera, Lily L. Wong, David J. Forsthoefel   +2 more
doaj   +2 more sources

Transcription Factors Active in the Anterior Blastema of Schmidtea mediterranea

Biomolecules, 2021
Regeneration, the restoration of body parts after injury, is quite widespread in the animal kingdom. Species from virtually all Phyla possess regenerative abilities. Human beings, however, are poor regenerators.
Yoko Suzuki-Horiuchi, Henning Schmitz, Carlotta Barlassina, David Eccles, Martina Sinn, Claudia Ortmeier, Sören Moritz, Luca Gentile   +7 more
doaj   +1 more source

Evolutionary dynamics of whole-body regeneration across planarian flatworms

Nature Ecology & Evolution, 2023
Regenerative abilities vary dramatically across animals. Even amongst planarian flatworms, well-known for complete regeneration from tiny body fragments, some species have restricted regeneration abilities while others are almost entirely regeneration ...
Miquel Vila‐Farré, Andrei Rozanski, Mario Ivanković, James Cleland, Jeremias N. Brand, Felix Thalén, Markus A. Grohme, Stephanie von Kannen, Alexandra L. Grosbusch, Hanh Thi-Kim Vu, Carlos E Prieto, F. Carbayo, B. Egger, Christoph Bleidorn, J. Rasko, J. Rink   +15 more
semanticscholar   +1 more source