Results 91 to 100 of about 10,466 (207)
SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.
PLoS Genetics, 2012 Planarian flatworms are able to both regenerate their whole bodies and continuously adapt their size to nutrient status. Tight control of stem cell proliferation and differentiation during these processes is the key feature of planarian biology.
Cristina González-Estévez +7 more
doaj +1 more source
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
BioEssays, Volume 47, Issue 9, September 2025.Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley +1 more source
Development, Growth and Differentiation, 2020 Planarians belong to the phylum Platyhelminthes and can regenerate their missing body parts after injury via activation of somatic pluripotent stem cells called neoblasts.
M. A. Auwal +8 more
semanticscholar +1 more source
MedComm – Biomaterials and Applications, Volume 4, Issue 3, September 2025.This review presents a precision delivery paradigm for inflammatory bowel disease, centered on Effective Transfer, Enhanced Retention, and Pathology‐targeting Treatment. Biomaterials and engineered platforms facilitate effective intestinal transit, prolonged mucosal retention, and respond to pathological cues, such as oxidative stress or immune ...
Ruoyi Gan, Enqi Ni, Guanyue Li, Wei Chen
wiley +1 more source
Biomarkers, 2020 Purpose To verify antioxidant responses and lipid peroxidation can be used as sensitive indicators for the risk assessment of the Wei River. Material and methods We investigate the effects of the Wei River on oxidative stress of planarian Dugesia ...
Yingyu Liu +4 more
semanticscholar +1 more source
A mex3 homolog is required for differentiation during planarian stem cell lineage development
eLife, 2015 Neoblasts are adult stem cells (ASCs) in planarians that sustain cell replacement during homeostasis and regeneration of any missing tissue. While numerous studies have examined genes underlying neoblast pluripotency, molecular pathways driving ...
Shu Jun Zhu +4 more
doaj +1 more source
Nature Neuroscience, 2017 All animals must detect noxious stimuli to initiate protective behavior, but the evolutionary origin of nociceptive systems is not well understood. Here we show that noxious heat and irritant chemicals elicit robust escape behaviors in the planarian ...
Oscar M. Arenas +5 more
semanticscholar +1 more source
Ets-1 transcription factor regulates glial cell regeneration and function in planarians [PDF]
, 2023 Bidushi Chandra +3 more
openalex +1 more source
eLife, 2019 Positional information is fundamental to animal regeneration and tissue turnover. In planarians, muscle cells express signaling molecules to promote positional identity.
Dayan J. Li, Conor L McMann, P. Reddien
semanticscholar +1 more source
BioMed Research International, 2019 Objective To investigate the effects of different concentrations of Fe3+ on the acute toxicity and regeneration of planarian at different temperatures.
X. Ding +6 more
semanticscholar +1 more source