Results 41 to 50 of about 10,466 (207)

A dual platform approach to transcript discovery for the planarian Schmidtea mediterranea to establish RNAseq for stem cell and regeneration biology.

open access: yesPLoS ONE, 2010
The use of planarians as a model system is expanding and the mechanisms that control planarian regeneration are being elucidated. The planarian Schmidtea mediterranea in particular has become a species of choice.
Martin J Blythe   +10 more
doaj   +1 more source

Planarians (Platyhelminthes)—An Emerging Model Organism for Investigating Innate Immune Mechanisms

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
An organism responds to the invading pathogens such as bacteria, viruses, protozoans, and fungi by engaging innate and adaptive immune system, which functions by activating various signal transduction pathways. As invertebrate organisms (such as sponges,
Luis Johnson Kangale   +9 more
doaj   +1 more source

Maintenance of Schmidtea mediterranea in the Laboratory

open access: yesBio-Protocol, 2018
In the last years, planarians have emerged as a unique model animal for studying regeneration and stem cells biology. Although their remarkable regenerative abilities are known for a long time, only recently the molecular tools to understand the biology ...
Nídia Sousa, Teresa Adell
doaj   +1 more source

Unusually Large Number of Mutations in Asexually Reproducing Clonal Planarian Dugesia japonica. [PDF]

open access: yesPLoS ONE, 2015
We established a laboratory clonal strain of freshwater planarian (Dugesia japonica) that was derived from a single individual and that continued to undergo autotomous asexual reproduction for more than 20 years, and we performed large-scale genome ...
Osamu Nishimura   +7 more
doaj   +1 more source

Cell quiescence in planarian stem cells, interplay between p53 and nutritional stimuli

open access: yesOpen Biology, 2022
Cell quiescence appeared early in evolution as an adaptive response to adverse conditions (i.e. nutrient depletion). In metazoans, quiescence has been involved in additional processes like tissue homeostasis, which is made possible by the presence of ...
Gaetana Gambino   +6 more
doaj   +1 more source

Sub-Lethal 5-Fluorouracil Dose Challenges Planarian Stem Cells Promoting Transcriptional Profile Changes in the Pluripotent Sigma-Class Neoblasts

open access: yesBiomolecules, 2021
Under physiological conditions, the complex planarian neoblast system is a composite of hierarchically organized stem cell sub-populations with sigma-class neoblasts, including clonogenic neoblasts, endowed with larger self-renewal and differentiation ...
Gaetana Gambino   +4 more
doaj   +1 more source

Autophagy-related Djatg8 is required for remodeling in planarian Dugesia japonica

open access: yesBiology Open, 2019
Planarians are the earliest free-living platyhelminthe with triploblastic and bilateral-symmetry. As an integral component of tissue homeostasis and regeneration, remodeling occurs constantly in the general planarian life history.
Jing Kang   +4 more
doaj   +1 more source

Djck1α Is Required for Proper Regeneration and Maintenance of the Medial Tissues in Planarians

open access: yesCells, 2023
CK1α (Casein kinase 1α) is a member of the casein kinase 1(CK1) family that is involved in diverse cellular processes, but its functions remain unclear in stem cell development.
Yongding Huang   +5 more
doaj   +1 more source

Planarian Anatomy Ontology: a resource to connect data within and across experimental platforms

open access: yesDevelopment, 2021
As the planarian research community expands, the need for an interoperable data organization framework for tool building has become increasingly apparent.
Stephanie H. Nowotarski   +8 more
semanticscholar   +1 more source

Transcriptome Analysis of the Planarian Eye Identifies ovo as a Specific Regulator of Eye Regeneration

open access: yesCell Reports, 2012
Among the millions of invertebrate species with visual systems, the genetic basis of eye development and function is well understood only in Drosophila melanogaster. We describe an eye transcriptome for the planarian Schmidtea mediterranea.
Sylvain W. Lapan, Peter W. Reddien
doaj   +1 more source

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