Results 61 to 70 of about 8,136,919 (335)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Contemporary industrial policy and challenges to South America and Brazil [PDF]

Brazilian Journal of Political Economy
We seek to identify the major vectors reconfiguring contemporary industrial policy in the US and the European Union to inform policymaking in South America and Brazil given their specific challenges to economic development.
CARLOS AGUIAR DE MEDEIROS, ESTHER MAJEROWICZ   +1 more
doaj   +1 more source

Angiogenic factors for planning fetal surveillance in fetal growth restriction and small‐for‐gestational‐age fetuses: A prospective observational study [PDF]

, 2022
Erika Bonacina, Manel Mendoza, Alba Farràs, Pablo García‐Manau, Berta Serrano, Ivan Hurtado, Raquel Ferrer‐Oliveras, Lidia Illan, Mireia Armengol‐Alsina, E. Carreras   +9 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Effectiveness of a Theory-Based Educational Intervention on the Constructs of the Health Action Process Approach (HAPA) Model and Sun Protective Behaviors in Male Students [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: The implementation of theory-based interventions is essential for the prevention of skin cancer among male adolescents, given their high levels of sun exposure and low adherence to preventive behaviors.
Qazal Olad Azimi, Isa Mohammadi Zeidi, Hadi Morshedi, Mohammadreza Maleki, Saeed Shahsavari, Amir Pakpoor   +5 more
doaj  

ANALYSIS AND PLANNING OF REGIONAL DEVELOPMENT - CONTEXTUAL VARIABLES TO DEVELOP A MODEL FOR MONITORING FINANCIAL INDICATORS AT REGIONAL LEVEL. [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2013
Application of quantitative techniques in regional analysis can provide an understanding of both the change in time of regional economic performance and the interdependencies between economic sectors, including the use of projections to test the ...
CRIS TINA GRADEA
doaj  

Inequality and segregation [PDF]

This paper explores the manner in which race and income interact to determine patterns of residential location in metropolitan areas. We use a framework in which individuals care about both the level of affluence and the racial composition of their ...
Rajiv Sethi, Rohini Somanathan
core  

Multi-Agent Planning with Planning Graph [PDF]

, 2003
In this paper, we consider planning for multi-agents situations in STRIPS-like domains with planning graph. Three possible relationships between agents' goals are considered in order to evaluate plans: the agents may be collaborative, adversarial or ...
Bui, The Duy, Jamroga, Wojciech
core   +2 more sources

New horizons for the methodology and physiology of training periodization: Block Periodization: New horizon or a false dawn? [PDF]

, 2010
It would appear premature to herald block periodization as a ‘new horizon’ in training planning, partly because of a fundamental lack of supporting evidence and clearly delineated rationale, and partly because contradictory evidence exists questioning ...
Balabinis, Beavan, Beavan, Bondarchuk, Bouchard, Brown, Brown, Davis, Dudley, Foster, Hennessy, Hickson, Hickson, Hickson, Hoff, Hoff, Hunter, Issurin, John Kiely, Kudielka, Matveyev, McCarthy, Mikkola, Mikkola, Millet, Nelson, Paavolainen, Rhea, Shaw, Skinner, Støren, Van Regenmortel, Verkhoshansky, Yamamoto   +33 more
core   +1 more source