Results 51 to 60 of about 8,515,584 (246)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Portfolio Methods for Optimal Planning: an Empirical Analysis [PDF]

, 2015
Combining the complementary strengths of several algorithms through portfolio approaches has been demonstrated to be effective in solving a wide range of AI problems. Notably, portfolio techniques have been prominently applied to suboptimal (satisficing)
Gerevini, Alfonso E., Vallati, Mauro, Hoos, Holger, Mattia Rizzini, Chris Fawcett, Gerevini, Alfonso Emilio, Fawcett, Chris, Holger H. Hoos, Rizzini, Mattia, Alfonso E. Gerevini, Hoos, Holger H., Mauro Vallati   +11 more
core   +1 more source

Planificación familiar en mujeres en condiciones de vulnerabilidad social Family planning for women in vulnerable social

Salud UIS, 2011
Introducción: La planificación familiar es un componente esencial en el cuidado de la salud primaria y reproductiva desatendida en poblaciones socialmente vulnerables.
Liliana Franco Hincapié, Gabriela María Mora Zapata, Ana Lucía Mosquera Hinestroza, Víctor Daniel Calvo Betancur   +3 more
doaj  

National growth models for stand basal area, volume, and biomass in Chinese larch plantations: integrating stand structure and species effects

Trees, Forests and People
Forest growth and yield models are essential tools for forest management decision-making, but most models have neglected the inclusion of stand structure. The relationship between stand structure and stand growth has been widely reported, but the results
Yangping Qin, Xiao He, Hong Guo, Chaofan Zhou, Weisheng Zeng, Xinyun Chen, Xiangdong Lei   +6 more
doaj   +1 more source

Eight heuristic planning techniques applied to three increasingly difficult wildlife planning problems

Silva Fennica, 2002
As both spatial and temporal characteristics of desired future conditions are becoming important measures of forest plan success, forest plans and forest planning goals are becoming complex.
Bettinger, Pete, Graetz, David, Boston, Kevin, Sessions, John, Chung, Woodam   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The principles of planning [1973]

, 1973
The Nature of Planning -- Essentials of Planning -- Comprehensive Program of Planning -- Planning Process -- planning ...
Kansas Department of Economic Development, State Planning Division
core   +1 more source

Knowledge engineering techniques for automated planning

, 2014
Formulating knowledge for use in AI Planning engines is currently some-thing of an ad-hoc process, where the skills of knowledge engineers and the tools they use may significantly influence the quality of the resulting planning application. There is little
Shah, M.
core   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Benchmarking energy consumption and solar energy potential for sustainable photovoltaic integration in university campus buildings

Scientific Reports
Integrating photovoltaic (PV) technologies has emerged as a crucial strategy to address Algeria’s energy, economic, and environmental challenges. Urgent solutions are needed with growing energy demand and limited renewable energy adoption.
Amina Bekkouche, Fatiha Benidir, Abdelhak Lekbir, Abdullahi Mohamed Samatar, Saad Mekhilef   +4 more
doaj   +1 more source