Results 101 to 110 of about 4,153,518 (252)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Chloroplast-genome-based insights into the systematic relationship of Eriobotrya (Rhaphiolepis)

iScience
Summary: The taxonomy of Eriobotrya and Rhaphiolepis has long been contentious due to unclear interspecific relationships, morphological ambiguities, low barcode resolution, and lack of molecular phylogenetic support.
Li Jin, Shaohong Qu, Wen Zhu, Qishao Li, Yunhong Tan, Zhengying Cao, Peiyao Xin, Yu Song   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Opportunities and challenges in the application of spatiotemporal transcriptomics in plant research

Frontiers in Plant Science
Spatiotemporal heterogeneity is recognized as a key driver of functional diversity in tissues. Spatial transcriptomics, which integrates high-throughput transcriptomics with high-resolution tissue imaging, enables the precise mapping of gene expression ...
Peilei Deng, Peilei Deng, Peilei Deng, Jiaruo Huang, Jiaruo Huang, Wencan He, Wencan He, Zhiyuan Li, Cun Guo, Cun Guo, Guoxin Chen, Xiaoxu Li, Xiaoxu Li, Xiaoxu Li, Kejun Zhong, Kejun Zhong, Wei Luo, Wei Luo, Bo Kong, Bo Kong   +19 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Impact of leading plant research centers of excellence on the scientific and socio-economic development in Europe

Frontiers in Research Metrics and Analytics
BackgroundCenters of Excellence (CoEs) are key instruments for advancing scientific excellence, innovation, and socio-economic development in Europe.MethodsThe paper compares three leading European Centers of Excellence in plant science: the Max Planck ...
Petar Kazakov, Petar Kazakov, Dimo Atanasov, Rositsa Beluhova, Marina Mircheva-Topalova, Asya Ivanova, Vesela Kazashka, Tsanko Gechev, Tsanko Gechev   +8 more
doaj   +1 more source

Application of genome editing in plant reproductive biology: recent advances and challenges

Key message: This comprehensive review underscores the application of genome editing in plant reproductive biology, including recent advances and challenges associated with it. Abstract: Genome editing (GE) is a powerful technology that has the potential
Watts, Anshul, Sankaranarayanan, Subramanian, Gawande, Nilesh D., Shelake, Rahul Mahadev, Bhalla, Hemal   +4 more
core   +1 more source

Recent Advances in Plant Chemical Biology of Jasmonates

, 2020
Lipid-derived plant hormone jasmonates are implicated in plant growth, reproductive performance, senescence, secondary metabolite productions, and defense against both necrotrophic pathogens and feeding insects. A major jasmonate is (+)-7-iso-jasmonoyl-l-
Ueda, Kaji, Kozaki
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source