Results 261 to 270 of about 525,389 (295)
Molecular Oncology, EarlyView.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Applied Biochemistry and Biotechnology, 1982 Plant cells have been immobilized in alginate, where they have been shown to retain their biological activity. Such systems can be utilized for bioconversions.
Klaus Mosbach, Peter E. Brodelius
openaire +4 more sources
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Current Opinion in Plant Biology, 2010
As our cover video illustrates, plant cells are very dynamic; their structure and molecular composition constantly changes as they progress through the cell cycle, divide, differentiate into specialised cell types, and respond to fluctuating environments. Progress in all of these areas is summarized in this issue.
Luschnig, C, Grierson, CS
openaire +4 more sources
As our cover video illustrates, plant cells are very dynamic; their structure and molecular composition constantly changes as they progress through the cell cycle, divide, differentiate into specialised cell types, and respond to fluctuating environments. Progress in all of these areas is summarized in this issue.
Luschnig, C, Grierson, CS
openaire +4 more sources
Current Opinion in Plant Biology, 1999
Molecular controls of the plant cell cycle must integrate environmental signals within developmental contexts. Recent advances highlight the fundamental conservation of underlying cell cycle mechanisms between animals and plants, overlaid by a rich molecular and regulatory diversity that is specific to plant systems.
Rachael P. Huntley, James A. H. Murray
openaire +3 more sources
Molecular controls of the plant cell cycle must integrate environmental signals within developmental contexts. Recent advances highlight the fundamental conservation of underlying cell cycle mechanisms between animals and plants, overlaid by a rich molecular and regulatory diversity that is specific to plant systems.
Rachael P. Huntley, James A. H. Murray
openaire +3 more sources