Results 131 to 140 of about 442,874 (256)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An ensemble heterogeneous transformer model for an effective diagnosis of multiple plant diseases. [PDF]

Front Plant Sci
Kalpana P, Gera P, Alabdulkreem E, Quasim MT, Baili J, Cho Y, Nam Y.   +6 more
europepmc   +1 more source

TrIncNet: a lightweight vision transformer network for identification of plant diseases. [PDF]

Front Plant Sci, 2023
Gole P, Bedi P, Marwaha S, Haque MA, Deb CK.   +4 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Research on the intelligent detection model of plant diseases based on MamSwinNet. [PDF]

Front Plant Sci
Zhang A, Liu W.
europepmc   +1 more source

Brevibacillus brevis HNCS-1: a biocontrol bacterium against tea plant diseases. [PDF]

Front Microbiol, 2023
Yang W, Yang H, Bao X, Hussain M, Bao Q, Zeng Z, Xiao C, Zhou L, Qin X.   +8 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

From triangle to pyramid: Understanding host-pathogen-microniome-environment interplay for sustainable, enviromics-empowered management of plant diseases. [PDF]

Plant Commun
Wang T, Hu W, Song W, Liao X, Zheng H, Zhang X, Xin X, Singh PK, Chen Y, Xu Y.   +9 more
europepmc   +1 more source

Recent co-evolution of two pandemic plant diseases in a multi-hybrid swarm. [PDF]

Nat Ecol Evol, 2023
Rahnama M, Condon B, Ascari JP, Dupuis JR, Del Ponte EM, Pedley KF, Martinez S, Valent B, Farman ML.   +8 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source