Results 131 to 140 of about 532,858 (293)

Transcriptome-wide association mapping provides insights into the genetic basis and candidate genes governing flowering, maturity and seed weight in rice bean (Vigna umbellata)

BMC Plant Biology
Background Rice bean (Vigna umbellata), an underrated legume, adapts to diverse climatic conditions with the potential to support food and nutritional security worldwide.
Tanmaya Kumar Sahu, Sachin Kumar Verma, Gayacharan, Nagendra Pratap Singh, Dinesh Chandra Joshi, D. P. Wankhede, Mohar Singh, Rakesh Bhardwaj, Badal Singh, Swarup Kumar Parida, Debasis Chattopadhyay, Gyanendra Pratap Singh, Amit Kumar Singh   +12 more
doaj   +1 more source

The Impact of Vavilov's Concept of the Centres of Crop Origin and Diversity on Research, Conservation, and Utilisation of Plant Genetic Resources Today: A Review on the Occasion of Vavilov's 135th Anniversary. [PDF]

Plants (Basel), 2023
Loskutov IG, Ebert AW, Diederichsen A.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterization of ridge gourd (Luffa acutangula) germplasm accessions for qualitative and seed quality traits

The Indian Journal of Agricultural Sciences
The study was carried out during summer seasons of 2021 and 2022 at ICAR-National Bureau of Plant Genetic Resources, New Delhi to evaluate 200 ridge gourd [Luffa acutangula (L.) Roxb.] germplasm accessions from India’s national genebank for 14 ...
MONIKA JHA, CHITHRA DEVI PANDEY, PRAVEEN KUMAR SINGH, SUNIL ARCHAK, MANJUSHA VERMA   +4 more
doaj   +1 more source

EURISCO update 2023: the European Search Catalogue for Plant Genetic Resources, a pillar for documentation of genebank material. [PDF]

Nucleic Acids Res, 2023
Kotni P, van Hintum T, Maggioni L, Oppermann M, Weise S.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Digitising biopiracy? The global governance of plant genetic resources in the age of digital sequencing information. [PDF]

Third World Q, 2022
Nehring R.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

On the Prospects of In Situ Conservation of Medicinal- and Aromatic-Plant Genetic Resources at Ancient-Hillfort Sites: A Case Study from Lithuania. [PDF]

Plants (Basel), 2023
Labokas J, Karpavičienė B.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source