Results 101 to 110 of about 2,893,681 (260)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1 [PDF]

, 2010
Fungal and oomycete plant pathogens translocate effector proteins into host cells to establish infection. However, virulence targets and modes of action of their effectors are unknown.
Hein, I., Dixelius, Christina, Hein, I, Hein, Ingo, Bryan, G, Dixelius, C., Kamoun, S., Gilroy, EM, Bos, JIB, Sadanandom, A, Boevink, PC, Gilroy, Eleanor M., Armstrong, MR, Bos, J. I. B., Taylor, RM, Bos, Jorunn I. B., Zhendong, T., Sadanandom, A., Boevink, Petra C., Dixelius, C, Engelhardt, Stefan, Bryan, Glenn, Birch, PRJ, Armstrong, M. R., Engelhardt, S, Hein, Ingo; id_orcid, Harrower, Brian, Kamoun, Sophien, Whisson, Stephen C., Vetukuri, R. R., Birch, Paul R. J.; id_orcid, Bryan, G., Vetukuri, RR, Engelhardt, S., Whisson, S. C., Tian, ZD, Whisson, SC, Boevink, P. C., Bryan, Glenn J., Bos, Jorunn, Gilroy, E. M., Sadanandom, Ari, Birch, Paul R. J., Harrower, B., Harrower, B, Vetukuri, Ramesh R., Birch, P. R. J., Taylor, R. M., Armstrong, Miles R., Taylor, Rosalind M., Zhendong, Tian, Kamoun, S, Tian, Zhendong, Sveriges lantbruksuniversitet., Ramesh, Vetukuri,, Dixelius, Christina,   +55 more
core   +1 more source

Analysing Novel Structures of Protein Complexes Requiring the Central Plant Immune Regulator EDS1 [PDF]

, 2013
Plants as sessile organisms are constantly attacked by pathogens and have evolved a complex immune system to cope with this challenge. The first inducible layer of plant immunity recognises pathogens outside each plant cell and activates a resistance ...
Wagner, Stephan
core   +1 more source

Genetic Diversity and Breeding Strategies for Resistance to Yellow Rust (Puccinia striiformis f. sp. tritici) in Wheat Hybrid Populations Based on Phenotypic and DNA Marker Screening

Plants
Yellow rust (Puccinia striiformis f. sp. tritici) is one of the most destructive diseases in wheat (Triticum aestivum L.) in Kazakhstan, causing significant yield losses. Owing to the high susceptibility of widely cultivated varieties, the development of
Saltanat Dubekova, Shynar Mazkirat, Dilyara Babissekova, Sholpan Khalbaeva, Amangeldy Sarbayev, Shynbolat Rsaliyev, Isatay Nurpeisov, Aydarkhan Yesserkenov   +7 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

A conserved Peptide pattern from a widespread microbial virulence factor triggers pattern-induced immunity in Arabidopsis [PDF]

, 2014
Microbe- or host damage-derived patterns mediate activation of pattern-triggered immunity (PTI) in plants. Microbial virulence factor (effector)-triggered immunity (ETI) constitutes a second layer of plant protection against microbial attack.
Albert, Isabell, Böhm, Hannah, Tom M Raaymakers, Isabell Albert (655450), Raaymakers, Tom M, Thorsten Nürnberger (655452), Hannah Böhm (655449), Van den Ackerveken, Guido, Guido Van den Ackerveken (115350), Thorsten Nürnberger, Plant Microbe Interactions, Nürnberger, Thorsten, Oome, Stan, Hannah Böhm, Guido Van den Ackerveken, Stan Oome (421709), Isabell Albert, Sub Plant-Microbe Interactions, Stan Oome, Tom M. Raaymakers (655451)   +19 more
core   +1 more source

NAC transcription factors in plant immunity

Phytopathology Research, 2019
The NAC (NAM, ATAF and CUC) family is one of the largest plant-specific transcription factor (TF) families. Members of this family are implicated in plant growth, development and stress responses.
Xi Yuan, Hui Wang, Jiating Cai, Dayong Li, Fengming Song   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Understanding the Plant Immune System

Molecular Plant-Microbe Interactions, 2010
Plant immunity is controlled by a complex signaling network. Here, we discuss how the complexity of the network affects our views and approaches in studying the plant immune network.
Fumiaki Katagiri, Kenichi Tsuda
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source