Results 81 to 90 of about 2,893,681 (260)

Keeping time on the plant-pathogen arms race : a role for the plant circadian clock in immune response [PDF]

, 2011
In this study, Arabidopsis thaliana (Arabidopsis) in the Columbia-0 (Col-0) background showed time-of-day variation in susceptibility to the plant-pathogen Pseudomonas syringae DC3000 pathovar tomato (P.
Bhardwaj, Vaibhav
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hormonal signaling in plant immunity [PDF]

, 2016
Insect hervivores and pathogens are a major problem in agriculture and therefore, control of these pests and diseases is essential. For this, understanding the plant immune response can be instrumental. The plant hormones salicylic acid (SA) and jasmonic
Sub Plant-Microbe Interactions, Plant Microbe Interactions, Caarls, L.   +2 more
core  

Extracellular DNA triggers glucosinolate-dependent defence responses against Frankliniella occidentalis

BMC Plant Biology
Background Extracellular self-DNA (exDNA) perception activates innate immunity in plants, inducing resistance to various agricultural pathogens and pests with different lifestyles.
Leila Rassizadeh, Antoni Garcia-Molina, Victor Flors, Isaac Vega-Muñoz, Jordi Gamir   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transcriptome-Wide Identification and Expression Analysis of Genes Encoding Defense-Related Peptides of Filipendula ulmaria in Response to Bipolaris sorokiniana Infection

Journal of Fungi
Peptides play an essential role in plant development and immunity. Filipendula ulmaria, belonging to the Rosaceae family, is a medicinal plant which exhibits valuable pharmacological properties. F.
Ekaterina A. Istomina, Tatyana V. Korostyleva, Alexey S. Kovtun, Marina P. Slezina, Tatyana I. Odintsova   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Phospholipase C2 affects MAMP-triggered immunity by modulating ROS production [PDF]

, 2017
The activation of phosphoinositide-specific phospholipase C (PI-PLC) is one of the earliest responses triggered by the recognition of several microbe-associated molecular patterns (MAMPs) in plants.
Laxalt, A.M., Laxalt, A. M., Fabro, Georgina, Juan Martín D’Ambrosio, Denise Scuffi, Lamattina, Lorenzo, Munnik, Teun, Andersson, M.X., Munnik, T., Zipfel, Cyril, Laxalt, Ana Maria, Couto, Daniel, D'Ambrosio, J. M., Andersson, Mats X., Andersson, Mats X.,, Álvarez, M.E., Ana M. Laxalt, Scuffi, Denise, Cyril Zipfel, D'Ambrosio, Juan Martín, Couto, D., Alvarez, M. E., Zipfel, C., María E. Álvarez, Álvarez, María E., Lamattina, L., Georgina Fabro, Alvarez, Maria Elena, Daniel Couto, Laxalt, Ana M., Mats X. Andersson, Scuffi, D., Lorenzo Lamattina, Fabro, G., D'Ambrosio, J.M., Teun Munnik   +35 more
core   +2 more sources