Results 41 to 50 of about 12,184 (261)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

High-generation near-isogenic lines combined with multi-omics to study the mechanism of polima cytoplasmic male sterility

BMC Plant Biology, 2021
Background Cytoplasmic male sterility (CMS), which naturally exists in higher plants, is a useful mechanism for analyzing nuclear and mitochondrial genome functions and identifying the role of mitochondrial genes in the plant growth and development ...
Benqi Wang, Zunaira Farooq, Lei Chu, Jie Liu, Huadong Wang, Jian Guo, Jinxing Tu, Chaozhi Ma, Cheng Dai, Jin Wen, Jinxiong Shen, Tingdong Fu, Bin Yi   +12 more
doaj   +1 more source

A REVIEW ON PHARMACOLOGICAL ACTIVITIES AND MEDICINAL USES OF ANISOPUS MANNII N.E.Br.

Zanco Journal of Pure and Applied Sciences, 2022
New plants with medical potential are being researched all around the world. Anisopus mannii is a herb currently utilized in traditional Northern Nigerian medicinal formulations.
Mahmoud Dogara Abdulrahman, Harmand A. Hama, Saber W. Hamad   +2 more
doaj   +1 more source

Medicinal plants used for treating infertility and related disorders of women in India: a systematic review

International Journal of Research in Medical Sciences, 2023
Assessment of plant medicine for treating infertility and related disorders is making headway universally recent couple of decades to bring out new effective and safe substances as an alternative medicine. Present paper reviews the published literature on plant medicine used for female infertility and related disorders.
Pramod Parasharam Sharma, Sakshi Pramod Sharma   +1 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Female Infertility and Herbal Medicine

Journal of Medicinal Plants, 2017
The causes of female infertility are multifaceted, and may extend to either of the partners or even both. Indeed, the root issues of infertility can be related to both sexes: approximately 50 percent of infertility is caused by female conditions, while ...
L Kashani, S Akhondzadeh
doaj  

Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa‐Ephb2 Pair

Advanced Science
Ovarian dysfunction is a major factor leading to female infertility. Understanding how to improve or reshape ovarian function has become an important entry point for preventing and treating female infertility caused by ovarian dysfunction.
Chunlan Mu, Xiaoyong Li, Jiamei Yang, Geng G. Tian, Hepeng Bai, Wenhui Lin, Linhui Wang, Ji Wu   +7 more
doaj   +1 more source

Plants Used in Chinese Medicine for the Treatment of Male Infertility Possess Antioxidant and Anti-Oestrogenic Activity [PDF]

Systems Biology in Reproductive Medicine, 2008
In this study Chinese herbs commonly used in the treatment of male infertility were investigated for relevant biochemical activity. Male factor infertility predominantly arises via barriers to, or defects in, spermatogenesis. The process of spermatogenesis is under strict endocrine control; in addition oxidative stress has been implicated in male ...
Helen G, Tempest, Sheryl T, Homa, Edwin J, Routledge, Anthony, Garner, Xiao-Ping, Zhai, Darren K, Griffin   +5 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source