Results 51 to 60 of about 2,692,204 (291)

HARNESSING PHYTOTHERAPY: EXPLORING ALTERNATIVE TREATMENTS FOR MALE INFERTILITY

Biota. Human. Technology
Purpose: The multifaceted nature of male infertility requires innovative approaches, leading researchers to explore the potential of phytotherapy to improve reproductive health.
Elizaveta Kadirova, Halina Tkaczenko, Piotr Kamiński, Oleksandr Lukash, Natalia Kurhaluk   +4 more
doaj   +1 more source

The Effect of Planting Date on the Characteristics Behavior of Rice Cultivars [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2013
A field experiment has conducted at the Wassit governorate during 2009 and 2010 growing season to study the effect of planting dates (1,15 June and 1 july ) on the Behavior characteristics four Rice cultivars (Baghdad, Menathera, Furat and Anber ...
Ryadh Jabar Mansoor
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Plants Used in Chinese Medicine for the Treatment of Male Infertility Possess Antioxidant and Anti-Oestrogenic Activity [PDF]

Systems Biology in Reproductive Medicine, 2008
In this study Chinese herbs commonly used in the treatment of male infertility were investigated for relevant biochemical activity. Male factor infertility predominantly arises via barriers to, or defects in, spermatogenesis. The process of spermatogenesis is under strict endocrine control; in addition oxidative stress has been implicated in male ...
Helen G, Tempest, Sheryl T, Homa, Edwin J, Routledge, Anthony, Garner, Xiao-Ping, Zhai, Darren K, Griffin   +5 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

YY males of the dioecious plant Mercurialis annua are fully viable but produce largely infertile pollen [PDF]

New Phytologist, 2019
Summary The suppression of recombination during sex‐chromosome evolution is thought to be favoured by linkage between the sex‐determining locus and sexually antagonistic loci, and leads to the degeneration of the chromosome restricted to the heterogametic sex ...
Xinji Li, Paris Veltsos, Guillaume G. Cossard, Jörn Gerchen, John R. Pannell   +4 more
openaire   +5 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

High-generation near-isogenic lines combined with multi-omics to study the mechanism of polima cytoplasmic male sterility

BMC Plant Biology, 2021
Background Cytoplasmic male sterility (CMS), which naturally exists in higher plants, is a useful mechanism for analyzing nuclear and mitochondrial genome functions and identifying the role of mitochondrial genes in the plant growth and development ...
Benqi Wang, Zunaira Farooq, Lei Chu, Jie Liu, Huadong Wang, Jian Guo, Jinxing Tu, Chaozhi Ma, Cheng Dai, Jin Wen, Jinxiong Shen, Tingdong Fu, Bin Yi   +12 more
doaj   +1 more source

Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome

Journal of Family and Reproductive Health, 2022
Objective: Polycystic ovarian syndrome is the most common cause of infertility and endocrine disorder among women due to anovulation. The aim of the present study is to investigate the effect of chamomile on oligomenorrhea and hirsutism symptoms as well
Malihe Afiat, Azam Akbari Lor, Mona Najaf Najafi, Masumeh Ghazanfarpour, Mina Jafarabadi   +4 more
doaj   +1 more source